DNA-(apurinic or apyrimidinic site) lyase

Known as: AP Endonuclease, Apurine Apyrimidine Endonuclease, Apurinic Endonuclease 
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA… (More)
National Institutes of Health

Papers overview

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Review
2010
Review
2010
DNA base excision repair (BER) is critically involved in the processing of DNA base damage induced by alkylating agents… (More)
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Highly Cited
2007
Highly Cited
2007
Cellular cytidine deaminases APOBEC3 family is a group of potent inhibitors for many exogenous and endogenous retroviruses. It… (More)
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Highly Cited
2004
Highly Cited
2004
The paradigm for repair of oxidized base lesions in genomes via the base excision repair (BER) pathway is based on studies in… (More)
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Highly Cited
2004
Highly Cited
2004
Osteosarcoma is the most common highly malignant bone tumor with primary appearance during the second and third decade of life… (More)
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Highly Cited
2001
Highly Cited
2001
The generation of reactive oxygen species in the cell provokes, among other lesions, the formation of 8-oxo-7,8-dihydroguanine (8… (More)
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2000
2000
The DNA base excision repair pathway is responsible for the repair of alkylation and oxidative DNA damage. A crucial step in the… (More)
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Highly Cited
1999
Highly Cited
1999
In vitro, following the removal of thymine from a G.T mismatch, thymine DNA glycosylase binds tightly to the apurinic site it has… (More)
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Highly Cited
1995
Highly Cited
1995
The major apurinic/apyrimidinic (AP) endonuclease of human cells, the Ape protein, incises DNA adjacent to abasic sites to… (More)
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Highly Cited
1991
Highly Cited
1991
Abasic (AP) sites are common, potentially mutagenic DNA damages that are attacked by AP endonucleases. The biological roles of… (More)
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Highly Cited
1990
Highly Cited
1990
DNA damage generated by oxygen radicals includes base-free apurinic/apyrimidinic (AP) sites and strand breaks that bear… (More)
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