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DNA-(apurinic or apyrimidinic site) lyase

Known as: AP Endonuclease, Apurine Apyrimidine Endonuclease, Apurinic Endonuclease 
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA… 
National Institutes of Health

Related topics

Related topics

18 relations
APEX1 geneDNA-(apurinic or apyrimidinic site) lyase activityIn BloodOGG1 gene

Narrower (6)

APEX1 protein, humanAPEX2 protein, humanAPLF protein, humanApex1 protein, rat

Broader (1)

Lyase

Papers overview

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2012
2012
Abstract 753: Pharmacokinetic profile of the base-excision repair inhibitor methoxyamine-HCl (TRC102; MX) given as an one-hour intravenous infusion with temozolomide (TMZ) in the first in human phase…
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Background: MX is the first base excision repair… 
2012
2012
Abstract 1743: Phase 1 clinical trial of the base-excision repair inhibitor Methoxyamine-HCl (TRC102; MX) in combination with Temozolomide (TMZ) in patients with solid tumors
Background: MX is the first base excision repair (BER) inhibitor evaluated in humans. MX blocks the BER pathway by covalently… 
2010
2010
AVersatile DNA Nanochip for Direct Analysis of DNA Base-Excision Repair * *
Direct observation of enzymes interacting with DNA should be one of the ultimate technologies for investigating the mechanical… 
1987
1987
[Specific for apurine-apyrimidine DNA endodeoxyribonuclease from the rat brain].
Endodeoxyribonuclease was detected in rat neocortex chromatin. The partly purified enzyme was found to influence the superhelical… 
1986
1986
Characterization and genetic mapping of a mutation affecting apurinic endonuclease activity in Staphylococcus aureus
Protoplast fusion between the Rec- mutant RN981 (L. Wyman, R. V. Goering, and R. P. Novick, Genetics 76:681-702, 1974) of… 
1982
1982
Action of T4 endonuclease V on polydeoxyribonucleotides with apyrimidinic or apurinic sites.
[3H]Thymine-labeled poly(dA) . poly(dT) carrying many apyrimidinic (AP) sites has been prepared by treating an enzymatically… 
1980
1980
Micrococcus luteus endonucleases for apurinic/apyrimidinic sites in deoxyribonucleic acid. 1. Purification and general properties.
Two chromatographically distinct endonucleases from Micrococcus luteus, specific for apurinic and apyrimidinic sites (AP… 
1980
1980
Micrococcus luteus endonucleases for apurinic/apyrimidinic sites in deoxyribonucleic acid. 2. Further studies on the substrate specificity and mechanism of action.
Two endonucleases specific for DNA-containing apurinic or apyrimidinic sites (AP-endonucleases A and B) have been isolated from… 
1977
1977
Mutations in Escherichia coli altering an apurinic endonuclease, endonuclease II, and exonuclease III and their effect on in vivo sensitivity to methylmethanesulfonate.
The levels of endonuclease II, an apurinic endonuclease, and exonuclease III in the parent strains (AB 1157) of Escherichia coli… 
1973
1973
DNA sequence restricted by restriction endonuclease AP from Haemophilus aphirophilus.
MANY bacterial strains contain strain-specific restriction endonucleases which degrade foreign DNA at a limited number of sites… 
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