DNA, Superhelical

Known as: DNA, Supertwisted, DNA, Superhelical [Chemical/Ingredient], Supertwisted DNA 
Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free… (More)
National Institutes of Health

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In BloodProcess of secretionagonistsantagonists & inhibitors
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Papers overview

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2010
2010
New Topoisomerase I mutations are associated with resistance to camptothecin
Topoisomerase I (TOP1) is a nuclear enzyme that catalyzes the relaxation of supercoiled DNA during DNA replication and… (More)
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Highly Cited
2003
Highly Cited
2003
Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.
THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and export… (More)
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2000
2000
Scanning force microscopy of the complexes of p53 core domain with supercoiled DNA.
We used scanning force microscopy to analyse the interaction of the core domain of the tumor suppressor protein p53 (p53CD, amino… (More)
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1997
1997
The effect of ionic conditions on the conformations of supercoiled DNA. I. Sedimentation analysis.
We studied the conformations of supercoiled DNA as a function of superhelicity and ionic conditions by determining its… (More)
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1995
1995
Preferential binding of human topoisomerase I to superhelical DNA.
Eukaryotic type I DNA topoisomerase provides swivels for removing torsional strain from the DNA helix during transcription and… (More)
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Highly Cited
1994
Highly Cited
1994
DNA transport by a type II DNA topoisomerase: Evidence in favor of a two-gate mechanism
DNA substrates in which a supercoiled DNA is singly linked to a nicked or relaxed DNA ring were used to analyze the transport of… (More)
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Highly Cited
1983
Highly Cited
1983
DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.
In order to study the double-strand DNA passage reaction of eukaryotic type II topoisomerases, a quantitative assay to monitor… (More)
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Highly Cited
1979
Highly Cited
1979
Purified Escherichia coli recA protein catalyzes homologous pairing of superhelical DNA and single-stranded fragments.
Purified Escherichia coli recA protein catalyzed ATP-dependent pairing of superhelical DNA and homologous single-stranded… (More)
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1978
1978
Spectrofluorometric measurement of the binding of ethidium to superhelical DNA from cell nuclei.
Structures retaining many of the morphological features of nuclei may be released by lysing HeLa cells in solutions containing… (More)
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1975
1975
Thermodynamic properties of superhelical DNAs.
Binding isotherms of ethidium to the superhelical DNA from phage PM2, and to PM2 DNA containing -1 single-chain scission per… (More)
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