DMP 323

Known as: 2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((4-(hydroxymethyl)phenyl)methyl)-4,7-bis(phenylmethyl)-, (4alpha,5alpha,6beta,7beta)-, DMP-323

National Institutes of Health

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2003

Catalytic carbonylation of functionalized diamines: application to the core structure of DMP 323 and DMP 450.

Keisha-Gay Hylton, A Denise Main, Lisa McElwee-White
The Journal of organic chemistry
2003

W(CO)(6)-catalyzed carbonylation provides an alternative to phosgene or phosgene derivatives such as 1,1-carbonyldiimidazole (CDI… (More)

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2000

Fusion of uninfected T-cells occurs with immature HIV-1 protease-mutant, but not morphologically similar protease inhibitor derived particles.

Mahmoud Bahmani, Minoru Kameoka, T. Goto, K. Sano, Ronald B. Luftig, Kazufumi Ikuta
Virus research
2000

Protease inhibitors are widely used in the treatment of human immunodeficiency virus type 1 (HIV-1)-infected individuals and show… (More)

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1996

Stereoselective Synthesis of HIV-1 Protease Inhibitor, DMP 323.

Michael E. Pierce, Gregory D. Harris, +6 authors George C. Emmett
The Journal of organic chemistry
1996

DMP 323, a potent HIV-1 protease inhibitor, has been synthesized by an efficient stereoselective process, amenable to large scale… (More)

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1994

Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cyclic urea, DMP 323.

Susan K Erickson-Viitanen, Ronald M. Klabe, Pam Cawood, Patricia L O'Neal, Jamy Meek
Antimicrobial agents and chemotherapy
1994

DMP 323 is a potent inhibitor of the protease of human immunodeficiency virus (HIV), with antiviral activity against both HIV… (More)

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1994

Pharmacokinetics of HIV protease inhibitor DMP 323 in rats and dogs.

Mary F. Grubb, Y. N. Wong, Daniel Burcham, Philip L. Saxton, Check Y. Quon, S. M. Huang
Drug metabolism and disposition: the biological…
1994

DMP 323 is a symmetrically substituted cyclic urea compound with demonstrated activity against human immunodeficiency virus (HIV… (More)

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1994

DMP 323, a nonpeptide cyclic urea inhibitor of human immunodeficiency virus (HIV) protease, specifically and persistently blocks intracellular processing of HIV gag polyprotein.

Mike Rayner, Bryan Cordova, +4 authors Patrick Lam
Antimicrobial agents and chemotherapy
1994

DMP 323, a C-2-symmetrical cyclic urea, is representative of a new class of inhibitors of human immunodeficiency virus protease… (More)

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DMP 323

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DMP 323

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