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DLL3 gene

Known as: DELTA, DROSOPHILA, HOMOLOG OF, SCDO1, DELTA-LIKE 3 
This gene is involved in both notch-mediated signaling and neurogenesis.
National Institutes of Health

Related topics

Related topics

4 relations
DLL4 geneDelta-Like Protein 3Jarcho-Levin syndromeSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Phase 1 study of AMG 757, a half-life extended bispecific T cell engager (BiTE) antibody construct targeting DLL3, in patients with small cell lung cancer (SCLC).
TPS8577 Background: SCLC is an aggressive neuroendocrine tumor; response to initial chemotherapy and radiotherapy is often… 
2018
2018
Delta-like 3 is silenced by HBx via histone acetylation in HBV-associated HCCs
Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. We previously showed that expression of Delta… 
2017
2017
An open-label study of rovalpituzumab tesirine in patients with DLL3-expressing advanced solid tumors.
TPS2597Background: Delta-like protein 3 (DLL3) is an inhibitory ligand of the Notch receptor family. It is highly expressed in… 
2017
2017
A study of rovalpituzumab tesirine in frontline treatment of patients with DLL3 expressing extensive small cell lung cancer.
TPS2598Background: Treatment and survival of SCLC patients (pts) has remained mostly unchanged over past decades with high… 
Review
2017
Review
2017
Prognostic value of DLL3 expression and clinicopathologic features in small cell bladder cancer (SCBC).
382Background: SCBC is rare with limited data on treatment and outcomes. DLL3, a Notch pathway protein, is expressed in small… 
2016
2016
Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues
Glioblastoma is the most common malignant brain tumor accounting for more than 54 % of all gliomas. Despite aggressive treatments… 
2007
2007
Dll3 is expressed in developing hair cells in the mammalian cochlea
Notch mediates the process of lateral inhibition that controls the production of hair cells in the inner ear. Hair cells are… 
2007
2007
Localization of functional Reelin receptors as revealed by alkaline phosphatase–Reelin fusion protein
2007
2007
A drastic change in gene expression profile of human neural progenitor cells under serum-free and serum-containing culture conditions
2002
2002
Diverse requirements for Notch signalling in mammals.
The Notch signalling pathway has a central role in a wide variety of developmental processes and it is not therefore surprising… 
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