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DLC1 protein, human

Known as: Rho GTPase-Activating Protein 7, Deleted in Liver Cancer 1 Protein, START Domain-Containing Protein 12 
Rho GTPase-activating protein 7 (1528 aa, ~171 kDa) is encoded by the human DLC1 gene. This protein is involved in the mediation of both signal… 
National Institutes of Health

Related topics

Related topics

14 relations
Breast CarcinomaCarcinoma of lungCell AdhesionColorectal Carcinoma

Broader (2)

GTPase-Activating ProteinsTumor Suppressor Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility
DLC-1 was originally identified as a potential tumor suppressor. One of the key biochemical functions of DLC-1 is to serve as a… 
Highly Cited
2008
Highly Cited
2008
DLC‐1 suppresses non‐small cell lung cancer growth and invasion by RhoGAP‐dependent and independent mechanisms
Expression of the tumor suppressor deleted in liver cancer‐1 (DLC‐1) is lost in non‐small cell lung (NSCLC) and other human… 
Highly Cited
2007
Highly Cited
2007
The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation
Identification of tumor suppressor genes (TSG) silenced by methylation uncovers mechanisms of tumorigenesis and identifies new… 
Highly Cited
2006
Highly Cited
2006
Aberrant Methylation and Deacetylation of Deleted in Liver Cancer-1 Gene in Prostate Cancer: Potential Clinical Applications
Purpose: The deleted in liver cancer-1 (DLC-1) gene that encodes a Rho GTPase-activating protein with tumor suppressor function… 
Highly Cited
2005
Highly Cited
2005
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells.
The identification of molecular signatures characteristic of tumor cells that are capable of metastatic spread is required for… 
Highly Cited
2004
Highly Cited
2004
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas
The deleted in liver cancer (DLC-1) gene at chromosome 8p21–22 is altered mainly by genomic deletion or aberrant promoter… 
Highly Cited
2004
Highly Cited
2004
Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells
The gene deleted in liver cancer-1 (DLC-1) is located on human chromosome 8p21–22, a region thought to harbor tumor suppressor… 
Highly Cited
2003
Highly Cited
2003
DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity
The human DLC-1 (deleted in liver cancer 1) gene was cloned from a primary human hepatocellular carcinoma (HCC) and mapped to the… 
Highly Cited
2000
Highly Cited
2000
DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1.
We investigated the expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having… 
Highly Cited
1997
Highly Cited
1997
I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain
The I kappaB alpha protein is a key molecular target involved in the control of NF-kappaB/Rel transcription factors during viral… 
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