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DIS3 gene

Known as: DIS3, KIAA1008, RIBOSOMAL RNA-PROCESSING PROTEIN 44, S. CEREVISIAE, HOMOLOG OF 
This gene is involved in RNA processing.
National Institutes of Health

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DIS3 wt Allele
HydrolysisRNA DegradationRNA Processing

Papers overview

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Highly Cited
2015
Highly Cited
2015
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
PURPOSE At the molecular level, myeloma is characterized by copy number abnormalities and recurrent translocations into the… Expand
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Highly Cited
2014
Highly Cited
2014
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.
We performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified… Expand
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Highly Cited
2014
Highly Cited
2014
Structure of an Rrp6-RNA exosome complex bound to polyA RNA
The eukaryotic RNA exosome processes and degrades RNA by directing substrates to the distributive or processive 3′ to 5… Expand
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Highly Cited
2012
Highly Cited
2012
Clonal evolution in relapsed acute myeloid leukemia revealed by whole genome sequencing
Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse, which is associated with clonal… Expand
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Highly Cited
2012
Highly Cited
2012
Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma.
We have used whole exome sequencing to compare a group of presentation t(4;14) with t(11;14) cases of myeloma to define the… Expand
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2010
2010
Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits.
The RNA processing exosome complex was originally defined as an evolutionarily conserved multisubunit complex of ribonucleases… Expand
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Highly Cited
2009
Highly Cited
2009
The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation
The exosome is a conserved macromolecular complex essential for RNA degradation. The nine-subunit core of the eukaryotic exosome… Expand
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Highly Cited
2007
Highly Cited
2007
A single subunit, Dis3, is essentially responsible for yeast exosome core activity
The conserved core of the exosome, the major eukaryotic 3′ → 5′ exonuclease, contains nine subunits that form a ring similar to… Expand
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Highly Cited
2007
Highly Cited
2007
Ribonuclease Activity of Dis3 Is Required for Mitotic Progression and Provides a Possible Link between Heterochromatin and Kinetochore Function
BACKGROUND Cellular RNA metabolism has a broad range of functional aspects in cell growth and division, but its role in… Expand
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Highly Cited
1997
Highly Cited
1997
The Exosome: A Conserved Eukaryotic RNA Processing Complex Containing Multiple 3′→5′ Exoribonucleases
We identified a complex in S. cerevisiae, the "exosome," consisting of the five essential proteins Rrp4p, Rrp41p, Rrp42p, Rrp43p… Expand
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