FAQ

DIS3 gene

Known as: DIS3, KIAA1008, RIBOSOMAL RNA-PROCESSING PROTEIN 44, S. CEREVISIAE, HOMOLOG OF 
This gene is involved in RNA processing.

Topic mentions per year

Topic mentions per year

1992-2017
051019922017

Related topics

Related topics

4 relations

Narrower (1)

DIS3 wt Allele
HydrolysisRNA DegradationRNA Processing

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
DIS3 gene
Hydrolysis
RNA Processing
RNA Degradation
DIS3 wt Allele

Papers overview

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2015
2015
The molecular spectrum and clinical impact of DIS3 mutations in multiple myeloma.
Multiple myeloma (MM) is a plasma cell neoplasm that presents with a major biological and clinical heterogeneity. We here… (More)
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2015
2015
DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.
Human DIS3, the nuclear catalytic subunit of the exosome complex, contains exonucleolytic and endonucleolytic active domains. To… (More)
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Highly Cited
2014
Highly Cited
2014
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.
We performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified… (More)
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2014
2014
Gene-dosage dependent overexpression at the 13q amplicon identifies DIS3 as candidate oncogene in colorectal cancer progression.
Colorectal cancer (CRC) development is in most cases marked by the accumulation of genomic alterations including gain of the… (More)
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Highly Cited
2012
Highly Cited
2012
Clonal evolution in relapsed acute myeloid leukemia revealed by whole genome sequencing
Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse, which is associated with clonal… (More)
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Highly Cited
2012
Highly Cited
2012
Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma.
We have used whole exome sequencing to compare a group of presentation t(4;14) with t(11;14) cases of myeloma to define the… (More)
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2011
2011
Pronounced and extensive microtubule defects in a Saccharomyces cerevisiae DIS3 mutant.
Subunits of the RNA processing exosome assemble into structurally distinct protein complexes that function in disparate cellular… (More)
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2009
2009
The Exosome Regulates Circadian Gene Expression in a Posttranscriptional Negative Feedback Loop
The eukaryotic circadian oscillators consist of autoregulatory negative feedback loops. However, little is known about the role… (More)
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2001
2001
A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes
Chromosomal region 13q21-q22 harbors a putative breast cancer susceptibility gene and has been implicated as a common site for… (More)
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1998
1998
Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3.
Saccharomyces cerevisiae Dis3p, which interacts with Ran/Gsp1p, complements Schizosaccharomyces pombe dis3-54. Consistent with… (More)
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