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DI-Leu16-IL2 Immunocytokine

Known as: De-Immunized Anti-CD20-IL-2 Immunocytokine DI-Leu16-IL-2 
A recombinant fusion protein consisting of de-immunized and humanized anti-CD20 monoclonal antibody Leu16 fused to human cytokine interleukin-2 (IL2… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
ABSTRACT We developed cergutuzumab amunaleukin (CEA-IL2v, RG7813), a novel monomeric CEA-targeted immunocytokine, that comprises… Expand
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2016
2016
Interest in combining radiotherapy and immune checkpoint therapy is growing rapidly. In this study, we explored a novel… Expand
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2015
2015
BACKGROUND AND PURPOSE Recently, we have shown that radiotherapy (RT) combined with the immunocytokine L19-IL2 can induce long… Expand
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Highly Cited
2013
Highly Cited
2013
Systemic high-dose IL2 promotes long-term survival in a subset of metastatic melanoma patients, but this treatment is accompanied… Expand
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2012
2012
Since a combination of flt3 ligand plasmid (pFL) and CpG-oligodeoxynucleotides (ODN)(3) as a dendritic cell (DC)-targeting double… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND L19-IL2, a tumour-targeting immunocytokine composed of the recombinant human antibody fragment L19 (specific to the… Expand
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2000
2000
The induction of tumor-protective immunity against malignancies remains a major challenge in cancer immunotherapy. A novel… Expand
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1998
1998
Immunocytokines are antibody-cytokine fusion proteins that combine the unique targeting ability of antibodies with the… Expand
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Highly Cited
1997
Highly Cited
1997
We examined the role of the cellular localization of antigen on the immune response after DNA immunization of mice with three… Expand
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Highly Cited
1985
Highly Cited
1985
To determine the changes in patterns of 17 beta-estradiol and progesterone levels underlying abnormal cycles in bitches immunized… Expand
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