DI-Leu16-IL2 Immunocytokine

Known as: De-Immunized Anti-CD20-IL-2 Immunocytokine DI-Leu16-IL-2 
A recombinant fusion protein consisting of de-immunized and humanized anti-CD20 monoclonal antibody Leu16 fused to human cytokine interleukin-2 (IL2… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2014
0119982014

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2014
2014
Rituximab (RTX), a chimeric IgG1 monoclonal antibody directed against the CD20 antigen, has revolutionized the treatment of B… (More)
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Review
2009
Review
2009
Patients with high risk melanoma and neuroblastoma frequently experience recurrence despite surgical resection and appropriate… (More)
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2008
2008
PURPOSE Effective control of pancreatic cancer has been hampered primarily by the lack of tumor specificity of current treatment… (More)
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2007
2007
Therapeutic treatment with hu14.18-IL-2 immunocytokine (IC) or Flt3-L (FL) protein is initially effective at resolving… (More)
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2006
2006
The immunocytokine scFvMEL/TNF, a fusion protein composed of human tumor necrosis factor (TNF) and a single-chain Fv antibody… (More)
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2005
2005
We have engineered an anti-CD20-interleukin 2 (IL-2) immunocytokine (ICK) based on the Leu16 anti-CD20 antibody and have… (More)
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2005
2005
The role of testosterone in the ovulatory process in hens has been largely neglected. The aim of the present study was to… (More)
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Review
2004
Review
2004
The health of 155 former workers in a US military research program who had received multiple vaccines and 265 matched community… (More)
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2001
2001
PURPOSE Immune-based therapies, such as the immunocytokine huKS-IL2, exert potent antitumor responses in some animal models by… (More)
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1998
1998
Immunocytokines are antibody-cytokine fusion proteins that combine the unique targeting ability of antibodies with the… (More)
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