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DHX58 gene

Known as: D11LGP2, DHX58, DEXH BOX POLYPEPTIDE 58 
 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness.
The RIG-I-like receptors (RLRs) signal innate immune defenses upon RNA virus infection, but their roles in adaptive immunity have… Expand
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2011
2011
The selective footprints of viral pressures at the human RIG-I-like receptor family.
The RIG-I-like receptors (RLRs)--RIG-I, IFIH1 (or MDA5) and LGP2--are thought to be key actors in the innate immune system, as… Expand
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Highly Cited
2010
Highly Cited
2010
LGP2 is a positive regulator of RIG-I-and MDA5-mediated antiviral responses
 
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Highly Cited
2010
Highly Cited
2010
LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses
RNA virus infection is recognized by retinoic acid-inducible gene (RIG)-I–like receptors (RLRs), RIG-I, and melanoma… Expand
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Highly Cited
2010
Highly Cited
2010
Evolutional Conservation of Molecular Structure and Antiviral Function of a Viral RNA Receptor, LGP2, in Japanese Flounder, Paralichthys olivaceus
LGP2 is an important intracellular receptor that recognizes viral RNAs in innate immunity. To understand the mechanism of viral… Expand
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Highly Cited
2009
Highly Cited
2009
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA
RIG-I and MDA5 sense cytoplasmic viral RNA and set-off a signal transduction cascade, leading to antiviral innate immune response… Expand
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Highly Cited
2009
Highly Cited
2009
Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.
  • X. Li, C. Lu, +4 authors P. Li
  • Archives of biochemistry and biophysics
  • 2009
    • Corpus ID: 8132202
RIG-I, MDA5 and LGP2 are cytosolic pattern recognition receptors detecting single-stranded or double-stranded RNA in virally… Expand
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Highly Cited
2009
Highly Cited
2009
A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2
ABSTRACT Diverse members of the Paramyxovirus family of negative-strand RNA viruses effectively suppress host innate immune… Expand
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Highly Cited
2007
Highly Cited
2007
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs). RNA binding and signaling by RIG-I are… Expand
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Highly Cited
2007
Highly Cited
2007
Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses
The DExD/H box RNA helicase retinoic acid-inducible gene I (RIG-I) and the melanoma differentiation-associated gene 5 (MDA5) are… Expand
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