DHX58 gene

Known as: D11LGP2, DHX58, DEXH BOX POLYPEPTIDE 58 
 
National Institutes of Health

Papers overview

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2015
2015
LGP2 plays extensive roles in modulating innate immune responses in Ctenopharyngodon idella kidney (CIK) cells.
LGP2 (laboratory of genetics and physiology 2), RIG-I (retinoic acid inducible gene-I) and MDA5 (melanoma differentiation… (More)
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2014
2014
Duck MDA5 functions in innate immunity against H5N1 highly pathogenic avian influenza virus infections
Melanoma differentiation-associated gene 5 (MDA5) is an important intracellular receptor that recognizes long molecules of viral… (More)
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2013
2013
Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs.
Poly(I:C), an agonist of TLR3 and RLRs, has been used as an immune adjuvant in clinical trials for many years. Although it has… (More)
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2012
2012
LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.
LGP2, a member of the RIG-I-like receptor family, lacks the amino-terminal caspase activation recruitment domains (CARDs… (More)
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2010
2010
Evolutional conservation of molecular structure and antiviral function of a viral RNA receptor, LGP2, in Japanese flounder, Paralichthys olivaceus.
LGP2 is an important intracellular receptor that recognizes viral RNAs in innate immunity. To understand the mechanism of viral… (More)
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Highly Cited
2010
Highly Cited
2010
LGP2 is a positive regulator of RIG-I-and MDA5-mediated antiviral responses
 
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2009
2009
A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2.
Diverse members of the Paramyxovirus family of negative-strand RNA viruses effectively suppress host innate immune responses… (More)
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2009
2009
Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.
RIG-I, MDA5 and LGP2 are cytosolic pattern recognition receptors detecting single-stranded or double-stranded RNA in virally… (More)
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Highly Cited
2007
Highly Cited
2007
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs). RNA binding and signaling by RIG-I are… (More)
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Highly Cited
2007
Highly Cited
2007
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses.
The DExD/H box RNA helicase retinoic acid-inducible gene I (RIG-I) and the melanoma differentiation-associated gene 5 (MDA5) are… (More)
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