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DHX58 gene

Known as: D11LGP2, DHX58, DEXH BOX POLYPEPTIDE 58 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
The antiviral innate immune response in fish: evolution and conservation of the IFN system.
Innate immunity constitutes the first line of the host defense after pathogen invasion. Viruses trigger the expression of… 
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Highly Cited
2010
Highly Cited
2010
LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses
RNA virus infection is recognized by retinoic acid-inducible gene (RIG)-I–like receptors (RLRs), RIG-I, and melanoma… 
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Highly Cited
2010
Highly Cited
2010
LGP2 is a positive regulator of RIG-I-and MDA5-mediated antiviral responses
Highly Cited
2009
Highly Cited
2009
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA
RIG-I and MDA5 sense cytoplasmic viral RNA and set-off a signal transduction cascade, leading to antiviral innate immune response… 
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Review
2009
Review
2009
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
The innate immune system responds within minutes of infection to produce type I interferons and pro-inflammatory cytokines… 
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Highly Cited
2009
Highly Cited
2009
Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.
RIG-I, MDA5 and LGP2 are cytosolic pattern recognition receptors detecting single-stranded or double-stranded RNA in virally… 
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Highly Cited
2009
Highly Cited
2009
A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2
ABSTRACT Diverse members of the Paramyxovirus family of negative-strand RNA viruses effectively suppress host innate immune… 
Highly Cited
2007
Highly Cited
2007
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs). RNA binding and signaling by RIG-I are… 
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Highly Cited
2007
Highly Cited
2007
Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses
The DExD/H box RNA helicase retinoic acid-inducible gene I (RIG-I) and the melanoma differentiation-associated gene 5 (MDA5) are… 
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Review
2006
Review
2006
TLR signaling
The Toll-like receptor (TLR) family plays an instructive role in innate immune responses against microbial pathogens, as well as… 
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