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DHX58 gene

Known as: D11LGP2, DHX58, DEXH BOX POLYPEPTIDE 58 
National Institutes of Health

Papers overview

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Review
2013
Review
2013
The antiviral innate immune response in fish: evolution and conservation of the IFN system.
Highly Cited
2010
Highly Cited
2010
LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses
RNA virus infection is recognized by retinoic acid-inducible gene (RIG)-I–like receptors (RLRs), RIG-I, and melanoma… 
Highly Cited
2010
Highly Cited
2010
LGP2 is a positive regulator of RIG-I-and MDA5-mediated antiviral responses
Highly Cited
2009
Highly Cited
2009
Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.
Highly Cited
2009
Highly Cited
2009
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA
RIG-I and MDA5 sense cytoplasmic viral RNA and set-off a signal transduction cascade, leading to antiviral innate immune response… 
Review
2009
Review
2009
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
Highly Cited
2009
Highly Cited
2009
A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2
ABSTRACT Diverse members of the Paramyxovirus family of negative-strand RNA viruses effectively suppress host innate immune… 
Highly Cited
2007
Highly Cited
2007
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs). RNA binding and signaling by RIG-I are… 
Highly Cited
2007
Highly Cited
2007
Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses
The DExD/H box RNA helicase retinoic acid-inducible gene I (RIG-I) and the melanoma differentiation-associated gene 5 (MDA5) are… 
Review
2006
Review
2006
TLR signaling
The Toll-like receptor (TLR) family plays an instructive role in innate immune responses against microbial pathogens, as well as… 
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