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DHCR24 gene

Known as: DESMOSTEROL DELTA-24-REDUCTASE, SELECTIVE AD INDICATOR 1, 24-DEHYDROCHOLESTEROL REDUCTASE 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma
3β-Hydroxysteroid-Δ24 reductase (DHCR24), the final enzyme of the cholesterol biosynthetic pathway, has been associated with… 
Review
2013
Review
2013
Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.
Review
2009
Review
2009
Cholesterol in Alzheimer's disease: unresolved questions.
The role of cholesterol as a susceptibility factor or a protective agent in neurodegeneration and, more generally, in amyloid… 
Highly Cited
2009
Highly Cited
2009
Down-regulation of Seladin-1 Increases BACE1 Levels and Activity through Enhanced GGA3 Depletion during Apoptosis*
Seladin-1 is a neuroprotective protein selectively down-regulated in brain regions affected in Alzheimer disease (AD). Seladin-1… 
Highly Cited
2008
Highly Cited
2008
Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content
The role of brain cholesterol in Alzheimer's disease (AD) is currently a matter of debate. Experimental evidence suggests that… 
Highly Cited
2008
Highly Cited
2008
3beta-Hydroxysteroid-delta24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis.
3beta-Hydroxysteroid-Delta24 reductase (DHCR24) is an endoplasmic reticulum-resident, multifunctional enzyme that possesses… 
Highly Cited
2005
Highly Cited
2005
Estrogen and selective estrogen receptor modulators exert neuroprotective effects and stimulate the expression of selective Alzheimer's disease indicator-1, a recently discovered antiapoptotic gene…
According to the fact that Alzheimer's disease (AD) is more common in postmenopausal women, estrogen treatment has been proposed… 
Highly Cited
2004
Highly Cited
2004
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
Expression of multiple oncogenes and inactivation of tumour suppressors is required to transform primary mammalian cells into… 
Highly Cited
2002
Highly Cited
2002
Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay.
Desmosterol (cholesta-5,24-dien-3beta-ol) is a minor sterol that forms as an intermediate in the cholesterol biosynthetic pathway… 
Highly Cited
2002
Highly Cited
2002
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer’s disease
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