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DEBIO-025

 
National Institutes of Health

Papers overview

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2010
2010
Muscular dystrophy results in the progressive wasting and necrosis of skeletal muscle. Glucocorticoids such as prednisone have… Expand
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2010
2010
Cyclophilin A is a peptidyl-propyl isomerase that binds the capsid (p24) protein of HIV-1 and facilitates replication. We report… Expand
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Highly Cited
2010
Highly Cited
2010
ABSTRACT The current standard of care for hepatitis C virus (HCV) infection, pegylated alpha interferon in combination with… Expand
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Highly Cited
2009
Highly Cited
2009
Viruses are obligate intracellular parasites and therefore their replication completely depends on host cell factors. In case of… Expand
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Highly Cited
2008
Highly Cited
2008
UNLABELLED Debio-025 is an oral cyclophilin (Cyp) inhibitor with potent anti-hepatitis C virus activity in vitro. Its effect on… Expand
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Highly Cited
2008
Highly Cited
2008
Muscular dystrophies comprise a diverse group of genetic disorders that lead to muscle wasting and, in many instances, premature… Expand
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Highly Cited
2008
Highly Cited
2008
ABSTRACT Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against… Expand
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Highly Cited
2007
Highly Cited
2007
Inhibition of mitochondrial permeability transition pore (mPTP) opening by cyclosporin A or ischemic postconditioning attenuates… Expand
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Highly Cited
2007
Highly Cited
2007
UNLABELLED Cyclosporin A (CsA) inhibits replication of the HCV subgenomic replicon, and this effect is believed to not be… Expand
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Highly Cited
2006
Highly Cited
2006
Cyclosporin A (CsA) inhibits the in vitro replication of HCV subgenomic replicons. We here report on the potent anti-HCV activity… Expand
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