DAG/PE-Binding Domain

Known as: C1 Domain, Diacylglycerol Binding Domain, Phorbol Ester Binding Domain 
The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain of PKC isoforms interacts with phorbol ester or with the… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
At the end of cell division, cytokinesis splits the cytoplasm of nascent daughter cells and partitions segregated sister genomes… (More)
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Highly Cited
2007
Highly Cited
2007
Synapses need to encode a wide dynamic range of action potential frequencies. Essential vesicle priming proteins of the Munc13… (More)
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Highly Cited
2007
Highly Cited
2007
The C1 domain mediates the diacylglycerol (DAG)-dependent translocation of conventional and novel protein kinase C (PKC) isoforms… (More)
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2004
2004
The lipid second messenger diacylglycerol acts by binding to the C1 domains of target proteins, which translocate to cell… (More)
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Review
2002
Review
2002
In recent years, there have been great advances in our understanding of the pharmacology and biology of the receptors for the… (More)
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2000
2000
Protein kinase C is specifically activated by binding two membrane lipids: the second messenger, diacylglycerol, and the amino… (More)
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Highly Cited
1998
Highly Cited
1998
As part of a cDNA library screen for clones that induce transformation of NIH 3T3 fibroblasts, we have isolated a cDNA encoding… (More)
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Highly Cited
1997
Highly Cited
1997
C1 domains are compact alpha/beta structural units of about 50 amino acids which tightly bind two zinc ions. These domains were… (More)
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1997
1997
Doc2 has two C2 domains that interact with Ca2+ and phospholipid. Munc13 has two C2 domains and one C1 domain that interacts with… (More)
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Highly Cited
1997
Highly Cited
1997
Activation of 44 and 42 kDa extracellular signal-regulated kinases (ERK)1/2 by angiotensin II (angII) plays an important role in… (More)
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