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DA 125

Known as: DA-125 
National Institutes of Health

Papers overview

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2005
2005
Inhibitory effect of DA-125, a new anthracyclin analog antitumor agent, on the invasion of human fibrosarcoma cells by down-regulating the matrix metalloproteinases.
2001
2001
DA-125, a novel anthracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway
Abstract. Purpose: DA-125 [(8S,10S)-8-(3-Aminopropanoyloxyacetyl)-10- [(2,6-dideoxy-2-fluoro-α-L-talopyranosyl)oxy]- 7,8,9,10… 
1998
1998
Phase I clinical trial: pharmacokinetics of a novel anthracycline, DA-125 and metabolites. Single dose study.
Single dose of DA-125, 20 (n = 3), 40 (n = 3), 60 (n = 3), 80 (n = 6), or 100 (n = 6) mg/m2 body surface area, was administered… 
1997
1997
Cellular uptake and antitumor activity of the new anthracycline analog DA-125 in human cancer cell lines
Abstract To predict the clinical usefulness of DA-125, a newly developed doxorubicin analog, we compared its antitumor activity… 
1997
1997
Pharmacokinetics of DA-125, a new anthracycline, after intravenous administration to spontaneously hypertensive rats and DOCA-salt-induced hypertensive rats.
Pharmacokinetic parameters-including tissue distribution, biliary excretion, and urinary excretion of M1-M4-were compared after… 
1997
1997
Antitumor activity of DA-125, a novel anthracycline, in human gastric and pulmonary adenocarcinoma cells resistant to adriamycin and cisplatin.
The study was undertaken to investigate the antitumor activity of DA-125, a promising new analogue of adriamycin (ADM) containing… 
1996
1996
Pharmacokinetics of DA-125, a new anthracycline, after intravenous administration to uranyl nitrate-induced acute renal failure rats or protein-calorie malnutrition rats.
The pharmacokinetics of DA-125 were compared after intravenous (i.v.) administration of the drug, 10 mg kg-1, to control male… 
1996
1996
Comparison of pharmacokinetics of M1, M2, M3, and M4 after intravenous administration of DA-125 or ME2303 to mice and rats. New adriamycin analogues containing fluorine.
The pharmacokinetics of M1, M2, M3 and/or M4 were compared after intravenous (i.v.) administration of DA-125 and/or ME2303 to… 
1996
1996
Pharmacokinetic changes of M1, M2, M3, and M4 after intravenous administration of a new anthracycline, DA-125, to alloxan-induced diabetes mellitus rats.
The pharmacokinetics of M1, M2, M3, and M4 were compared after intravenous (i.v.) administration of DA-125, 15 mg/kg to the… 
1993
1993
A Study on Cardiotoxicity of DA-125, a New Anticancer Antibiotic
DA-125, a new anthracycline antibiotic, showed antitumor activity against animal tumors and human tumors. Therefore we studied… 
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