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D-serine biosynthetic process

Known as: D-serine anabolism, D-serine synthesis, D-serine biosynthesis 
The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D… 
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle
Significance Phgdh is a crucial enzyme in the astrocytic synthesis of l-serine from glucose. Our study uncovers the role of glial… 
2018
2018
ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment
Significance d-serine regulates synaptic plasticity and behavior by binding to the NMDA receptors. Astrocyte–neuron cross-talk… 
2017
2017
Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
It is long acknowledged that the N-methyl d-aspartate receptor co-agonist, d-serine, plays a crucial role in several N-methyl d… 
2017
2017
D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO2 and pH homeostasis… 
2017
2017
Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks
We provide evidence that NMDARs within murine spinal locomotor networks determine the frequency and amplitude of ongoing… 
2014
2014
FBXO22 Protein Is Required for Optimal Synthesis of the N-Methyl-d-Aspartate (NMDA) Receptor Coagonist d-Serine*
Background: Serine racemase produces d-serine, which is required for optimal NMDA receptor activity. Results: FBXO22 interacts… 
Review
2010
Review
2010
N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?
Highly Cited
2009
Highly Cited
2009
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.
Abnormal N-methyl-d-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. d-serine is… 
Review
2008
Review
2008
d‐Amino acids in the brain: the biochemistry of brain serine racemase
It has been recently established that in various brain regions d‐serine, the product of serine racemase, occupies the so‐called… 
Highly Cited
2001
Highly Cited
2001
A new strategy to decrease N-methyl-d-aspartate (NMDA) receptor coactivation: Inhibition of d-serine synthesis by converting serine racemase into an eliminase
Serine racemase is a brain-enriched enzyme that synthesizes d-serine, an endogenous modulator of the glycine site of N-methyl-d… 
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