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D-serine biosynthetic process

Known as: D-serine anabolism, D-serine synthesis, D-serine biosynthesis 
The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle.
Astrocytes express the 3-phosphoglycerate dehydrogenase (Phgdh) enzyme required for the synthesis of l-serine from glucose… Expand
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2018
2018
ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment.
d-serine is a physiologic coagonist of NMDA receptors, but little is known about the regulation of its synthesis and synaptic… Expand
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2017
2017
Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
It is long acknowledged that the N-methyl d-aspartate receptor co-agonist, d-serine, plays a crucial role in several N-methyl d… Expand
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2017
2017
D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO2 and pH homeostasis… Expand
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2017
2017
Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks
Activation of N-methyl-d-aspartate receptors (NMDARs) requires the binding of a coagonist, either d-serine or glycine, in… Expand
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2014
2014
FBXO22 Protein Is Required for Optimal Synthesis of the N-Methyl-d-Aspartate (NMDA) Receptor Coagonist d-Serine*
Background: Serine racemase produces d-serine, which is required for optimal NMDA receptor activity. Results: FBXO22 interacts… Expand
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Review
2010
Review
2010
N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?
Schizophrenia is a severe mental disorder associated with a characteristic constellation of symptoms and neurocognitive deficits… Expand
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Highly Cited
2009
Highly Cited
2009
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.
Abnormal N-methyl-d-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. d-serine is… Expand
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Review
2008
Review
2008
D-amino acids in the brain: the biochemistry of brain serine racemase.
It has been recently established that in various brain regions D-serine, the product of serine racemase, occupies the so-called… Expand
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2001
2001
A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor coactivation: inhibition of D-serine synthesis by converting serine racemase into an eliminase.
Serine racemase is a brain-enriched enzyme that synthesizes d-serine, an endogenous modulator of the glycine site of N-methyl-d… Expand
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