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D-serine biosynthetic process
Known as:
D-serine anabolism
, D-serine synthesis
, D-serine biosynthesis
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The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle
S. Neame
,
Hazem Safory
,
+9 authors
Herman Wolosker
Proceedings of the National Academy of Sciences
2019
Corpus ID: 202745636
Significance Phgdh is a crucial enzyme in the astrocytic synthesis of l-serine from glucose. Our study uncovers the role of glial…
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2018
2018
ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment
Eitan Kaplan
,
S. Zubedat
,
+14 authors
Herman Wolosker
Proceedings of the National Academy of Sciences
2018
Corpus ID: 52161638
Significance d-serine regulates synaptic plasticity and behavior by binding to the NMDA receptors. Astrocyte–neuron cross-talk…
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2017
2017
Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
Tommaso Nuzzo
,
S. Sacchi
,
+11 authors
A. Usiello
npj Schizophrenia
2017
Corpus ID: 4630718
It is long acknowledged that the N-methyl d-aspartate receptor co-agonist, d-serine, plays a crucial role in several N-methyl d…
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2017
2017
D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
S. Beltrán-Castillo
,
M. J. Olivares
,
+4 authors
J. Eugenín
Nature Communications
2017
Corpus ID: 3283885
Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO2 and pH homeostasis…
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2017
2017
Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks
David Acton
,
G. Miles
Journal of neurophysiology
2017
Corpus ID: 1923903
We provide evidence that NMDARs within murine spinal locomotor networks determine the frequency and amplitude of ongoing…
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2014
2014
FBXO22 Protein Is Required for Optimal Synthesis of the N-Methyl-d-Aspartate (NMDA) Receptor Coagonist d-Serine*
Elena Dikopoltsev
,
V. Foltyn
,
+4 authors
Herman Wolosker
The Journal of Biological Chemistry
2014
Corpus ID: 32397837
Background: Serine racemase produces d-serine, which is required for optimal NMDA receptor activity. Results: FBXO22 interacts…
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Review
2010
Review
2010
N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?
J. Kantrowitz
,
D. Javitt
Brain Research Bulletin
2010
Corpus ID: 24554234
Highly Cited
2009
Highly Cited
2009
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.
V. Labrie
,
R. Fukumura
,
+12 authors
J. Roder
Human molecular genetics
2009
Corpus ID: 2133182
Abnormal N-methyl-d-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. d-serine is…
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Review
2008
Review
2008
d‐Amino acids in the brain: the biochemistry of brain serine racemase
F. Baumgart
,
I. Rodrı́guez-Crespo
The FEBS journal
2008
Corpus ID: 23197041
It has been recently established that in various brain regions d‐serine, the product of serine racemase, occupies the so‐called…
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Highly Cited
2001
Highly Cited
2001
A new strategy to decrease N-methyl-d-aspartate (NMDA) receptor coactivation: Inhibition of d-serine synthesis by converting serine racemase into an eliminase
R. Panizzutti
,
J. de Miranda
,
C. S. Ribeiro
,
S. Engelender
,
Herman Wolosker
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 11565173
Serine racemase is a brain-enriched enzyme that synthesizes d-serine, an endogenous modulator of the glycine site of N-methyl-d…
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