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D-serine biosynthetic process

Known as: D-serine anabolism, D-serine synthesis, D-serine biosynthesis 
The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2017
02420012017

Papers overview

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2018
2018
Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features.
d-Serine is a co-agonist at forebrain N-methyl-d-aspartate receptors (NMDAR) and is synthesized by serine racemase (SR). Although… (More)
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2017
2017
Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
It is long acknowledged that the N-methyl d-aspartate receptor co-agonist, d-serine, plays a crucial role in several N-methyl d… (More)
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2017
2017
D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO2 and pH homeostasis… (More)
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2017
2017
Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks
Activation of N-methyl-d-aspartate receptors (NMDARs) requires the binding of a coagonist, either d-serine or glycine, in… (More)
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2017
2017
Neuron—glia interactions: Waking the synapse
to neuromodulators, coupled with their ability to influence neuronal activity through the release of ‘gliotransmitters’, suggests… (More)
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2014
2014
FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.
d-Serine is a physiological activator of NMDA receptors (NMDARs) in the nervous system that mediates several NMDAR-mediated… (More)
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2010
2010
EphrinBs regulate D-serine synthesis and release in astrocytes.
There is growing evidence that astrocytes play critical roles in neuron-glial interactions at the synapse. Astrocytes are… (More)
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Review
2010
Review
2010
N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?
Schizophrenia is a severe mental disorder associated with a characteristic constellation of symptoms and neurocognitive deficits… (More)
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Highly Cited
2009
Highly Cited
2009
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.
Abnormal N-methyl-d-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. d-serine is… (More)
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2001
2001
A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor coactivation: inhibition of D-serine synthesis by converting serine racemase into an eliminase.
Serine racemase is a brain-enriched enzyme that synthesizes d-serine, an endogenous modulator of the glycine site of N-methyl-d… (More)
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