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Cytochrome P450 2A5

Mouse cytochrome P450 2a5 protein (494 aa, 57 kD) is encoded by the mouse Cyp2a5 gene. This enzyme is an unspecific, membrane-bound, monooxygenase… 
National Institutes of Health

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Cytochrome P450Mus

Papers overview

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2017
2017
Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver
BackgroundCytochrome P450 2A5 (Cyp2a5), a mouse enzyme orthologous of human CYP2A6, catalyzes a number of toxicologically… 
2013
2013
Cytochrome P450 2A5 and bilirubin: mechanisms of gene regulation and cytoprotection.
Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been… 
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2013
2013
Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation☆
Mouse cytochrome P450 2A5 (CYP2A5) is upregulated in various liver diseases and a putative common feature for all of these… 
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2011
2011
Inducible bilirubin oxidase: a novel function for the mouse cytochrome P450 2A5.
We have previously shown that bilirubin (BR), a breakdown product of haem, is a strong inhibitor and a high affinity substrate of… 
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2010
2010
Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver.
Mouse cytochrome P450 2A5 (CYP2A5) is upregulated in various pathophysiological liver diseases and induced by structurally… 
2008
2008
Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.
Murine hepatic cytochrome P450 2A5 (CYP2A5), unlike most CYP enzymes, is upregulated during hepatitis and hepatotoxic conditions… 
2008
2008
Microarray analysis of hepatic gene expression in pyrazole-mediated hepatotoxicity: identification of potential stimuli of Cyp2a5 induction.
Cytochrome P450 2a5 (Cyp2a5) expression is induced during liver damage caused by hepatotoxins such as pyrazole, however, the… 
2005
2005
Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.
Oxidative metabolism of bilirubin (BR) -- a breakdown product of haem with cytoprotective and toxic properties -- is an important… 
Highly Cited
2004
Highly Cited
2004
Endoplasmic Reticulum Stress Due to Altered Cellular Redox Status Positively Regulates Murine Hepatic CYP2A5 Expression
Murine hepatic cytochrome P450 2A5 (CYP2A5) is uniquely induced by a variety of agents that cause liver injury and inflammation… 
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2003
2003
Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.
Murine hepatic cytochrome P450 2a5 (Cyp2a5) is induced during hepatotoxicity and hepatitis, however, the specific regulatory… 
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