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Cytochrome P450 26A1, human

Known as: Cytochrome P450RAI, Retinoic Acid-Metabolizing Cytochrome, EC 1.14.-.- 
Cytochrome P450 26A1 (497 aa, ~56 kDa) is encoded by the human CYP26A1 gene. This protein is involved in the hydroxylation of retinoic acid.
National Institutes of Health

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13 relations
CYP26A1 geneCytochrome P450 26B1, humanEnzyme GeneHemeproteins

Broader (1)

retinoic acid 4-hydroxylase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Retinoic acid-metabolizing enzyme cytochrome P450 26A1 promotes skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Elevated expression of the retinoic acid-metabolizing enzyme cytochrome P450 26A1 (CYP26A1) has been demonstrated to have an… 
2016
2016
Dietary vitamin A supplementation improved reproductive performance by regulating ovarian expression of hormone receptors, caspase-3 and Fas in broiler breeders.
The effects of dietary vitamin A (VA) supplementation on reproductive performance, VA deposition, and potential mechanisms of… 
2016
2016
Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy
Cytochrome P450 26A1 (CYP26A1) has a spatiotemporal expression pattern in the uterus, with a significant increase in mRNA and… 
Highly Cited
2015
Highly Cited
2015
Triphenyl phosphate-induced developmental toxicity in zebrafish: potential role of the retinoic acid receptor.
2013
2013
Regulation of cyp26a1 on Th17 cells in mouse peri-implantation
Cytochrome P450 26A1 (cyp26a1) is expressed in the mouse uterus during peri‐implantation. The repression of this protein is… 
2012
2012
Retinoic acid synthesis and metabolism are concurrent in the mouse uterus during peri-implantation
Vitamin A (retinol) and its active metabolite, retinoic acid (RA), serve dual roles in the female reproductive tract. Cytochrome… 
2011
2011
Altered expression of both β-carotene 15,15' monooxygenase and lecithin:retinol acyltransferase in obese Zucker rats.
Retinol and its active derivative retinoic acid have an important role in development, reproduction, immunity, and cell… 
Highly Cited
2008
Highly Cited
2008
Ligand Activation of Peroxisome Proliferator-Activated Receptor-β/δ Inhibits Cell Proliferation in Human HaCaT Keratinocytes
Although there is strong evidence that ligand activation of peroxisome proliferator-activated receptor (PPAR)-β/δ induces… 
2004
2004
Identification of the Fenretinide Metabolite 4-Oxo-Fenretinide Present in Human Plasma and Formed in Human Ovarian Carcinoma Cells through Induction of Cytochrome P450 26A1
Purpose: The synthetic retinoid fenretinide (4-HPR) exhibits preventive and therapeutic activity against ovarian tumors. An… 
Highly Cited
1997
Highly Cited
1997
cDNA Cloning of Human Retinoic Acid-metabolizing Enzyme (hP450RAI) Identifies a Novel Family of Cytochromes P450 (CYP26)*
Retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA play important roles in regulating gene… 
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