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Cytochrome P450 26A1, human

Known as: Cytochrome P450RAI, Retinoic Acid-Metabolizing Cytochrome, EC 1.14.-.- 
Cytochrome P450 26A1 (497 aa, ~56 kDa) is encoded by the human CYP26A1 gene. This protein is involved in the hydroxylation of retinoic acid.
National Institutes of Health

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13 relations
CYP26A1 geneCytochrome P450 26B1, humanEnzyme GeneHemeproteins
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Broader (1)

retinoic acid 4-hydroxylase

Papers overview

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2018
2018
Retinoic acid-metabolizing enzyme cytochrome P450 26A1 promotes skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Elevated expression of the retinoic acid-metabolizing enzyme cytochrome P450 26A1 (CYP26A1) has been demonstrated to have an… Expand
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2017
2017
Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy
Cytochrome P450 26A1 (CYP26A1) has a spatiotemporal expression pattern in the uterus, with a significant increase in mRNA and… Expand
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2016
2016
Dietary vitamin A supplementation improved reproductive performance by regulating ovarian expression of hormone receptors, caspase-3 and Fas in broiler breeders.
The effects of dietary vitamin A (VA) supplementation on reproductive performance, VA deposition, and potential mechanisms of… Expand
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2015
2015
Triphenyl phosphate-induced developmental toxicity in zebrafish: potential role of the retinoic acid receptor.
Using zebrafish as a model, we previously reported that developmental exposure to triphenyl phosphate (TPP) - a high-production… Expand
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2012
2012
Retinoic acid synthesis and metabolism are concurrent in the mouse uterus during peri-implantation
Vitamin A (retinol) and its active metabolite, retinoic acid (RA), serve dual roles in the female reproductive tract. Cytochrome… Expand
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2011
2011
Altered expression of both β-carotene 15,15' monooxygenase and lecithin:retinol acyltransferase in obese Zucker rats.
Retinol and its active derivative retinoic acid have an important role in development, reproduction, immunity, and cell… Expand
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2008
2008
Ligand Activation of Peroxisome Proliferator-Activated Receptor-/ Inhibits Cell Proliferation in Human HaCaT Keratinocytes
Although there is strong evidence that ligand activation of peroxisome proliferator-activated receptor (PPAR)/ induces terminal… Expand
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2004
2004
Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.
PURPOSE The synthetic retinoid fenretinide (4-HPR) exhibits preventive and therapeutic activity against ovarian tumors. An… Expand
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2001
2001
Effects of hp450RAI plasmid transfection on cellular function and IFN-α expression of HL-60 cells
ObjectiveTo investigate the effects of human cytochrome P450 enzyme gene(hp450RAI)transfer on retinoic acid metabolism and… Expand
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Highly Cited
1997
Highly Cited
1997
cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450.
Retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA play important roles in regulating gene… Expand
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