Cytochrome P-450 CYP3A5

Known as: P-450 CYP3A5, Cytochrome, Cytochrome P450 3A5, CYP3A5 
A specific subtype of CYP3A.
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
CYP3A4 and CYP3A5 exhibit significant overlap in substrate specificity but can differ in product regioselectivity and formation… (More)
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Highly Cited
2004
Highly Cited
2004
ABSTRACTThe required dose of the oral anticoagulant warfarin varies greatly, and overdosing often leads to bleeding. Warfarin is… (More)
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Highly Cited
2003
Highly Cited
2003
We systematically characterized the oxidative metabolites of 17beta-estradiol and estrone formed by 15 human cytochrome P450 (CYP… (More)
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Highly Cited
2003
Highly Cited
2003
Tacrolimus is a substrate for P-glycoprotein (P-gp) and cytochrome (CYP) P4503A. P-gp is encoded by the multiple drug resistance… (More)
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Highly Cited
2002
Highly Cited
2002
We recently demonstrated that a variant allele of CYP3A5 (CYP3A5*3) confers low CYP3A5 expression as a result of improper mRNA… (More)
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Highly Cited
2002
Highly Cited
2002
The elucidation of the individual contributions of the four CYP3A genes to the overall CYP3A activity has been hampered by… (More)
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Highly Cited
2002
Highly Cited
2002
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The… (More)
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Highly Cited
2001
Highly Cited
2001
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid levels and responses to half of all… (More)
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Highly Cited
2001
Highly Cited
2001
CYP3A proteins comprise a significant portion of the hepatic cytochrome P450 (CYP) protein and they metabolize around 50% of… (More)
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Highly Cited
1999
Highly Cited
1999
The purpose of this study was to compare the kinetics of intestinal and hepatic cytochrome P-450 3A (CYP3A) inhibition by using… (More)
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