Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Cystic Fibrosis Transmembrane Conductance Regulator

Known as: CFTR, CFTR Protein, cystic fibrosis transmembrane conductance regulator (CFTR) protein 
A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum… Expand
National Institutes of Health

Related topics

Related topics

12 relations
CFTR geneCystic FibrosisIn BloodProcess of secretion
Expand

Broader (1)

Chloride Channels

Narrower (1)

cystic fibrosis transmembrane conductance regulator delta F508

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL.
The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP binding cassette (ABC) transporter superfamily… Expand
Review
2018
Review
2018
Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology
Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis Transmembrane Conductance… Expand
  • figure 1
Highly Cited
2014
Highly Cited
2014
Clinical mechanism of the cystic fibrosis transmembrane conductance regulator potentiator ivacaftor in G551D-mediated cystic fibrosis.
RATIONALE Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator recently approved for patients… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Highly Cited
2004
Highly Cited
2004
Structure of nucleotide‐binding domain 1 of the cystic fibrosis transmembrane conductance regulator
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP‐binding cassette (ABC) transporter that functions as a… Expand
Highly Cited
1996
Highly Cited
1996
Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor
Mice that have been made deficient for the cystic fibrosis transmembrane conductance regulator (Cftr) usually die of intestinal… Expand
Highly Cited
1994
Highly Cited
1994
Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.
The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl- channel regulated by protein kinase A. The… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Highly Cited
1992
Highly Cited
1992
Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)
Circumstantial evidence has accumulated suggesting that CFTR is a regulated low-conductance Cl- channel. To test this postulate… Expand
Highly Cited
1992
Highly Cited
1992
In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
Direct transfer of the normal cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene to airway epithelium was… Expand
Highly Cited
1991
Highly Cited
1991
Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.
Cystic fibrosis (CF) is characterized by an abnormality in cAMP-regulated chloride transport that results from a primary defect… Expand
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Highly Cited
1990
Highly Cited
1990
Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells
The cystic fibrosis transmembrane conductance regulator (CFTR) was expressed in cultured cystic fibrosis airway epithelial cells… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE