Cyclic Nucleotide Phosphodiesterases, Type 4

Known as: Type 4 Cyclic Nucleotide Phosphodiesterase, PDE4 Phosphodiesterases, Phosphodiesterase IV 
A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL… (More)
National Institutes of Health

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Cyclic Nucleotide Phosphodiesterases, Type 4CPDE4B protein, humanPDE4B protein, ratphosphodiesterase 4B
In BloodProcess of secretionaspects of radiation effectschemical synthesis
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Broader (1)

phosphoric diester hydrolase

Papers overview

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Review
2009
Review
2009
Systemic manifestations and comorbidities of COPD.
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow… (More)
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Review
2009
Review
2009
Glucocorticoid resistance in inflammatory diseases
Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases-including… (More)
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Highly Cited
2009
Highly Cited
2009
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The efficacy and safety of… (More)
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Highly Cited
2009
Highly Cited
2009
Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 (PDE4) inhibitor rolipram on behavior depend on cyclic AMP-response element binding protein (CREB)-mediated neurogenesis in the…
Inhibition of phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP (cAMP), increases phosphorylation… (More)
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Review
2007
Review
2007
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling.
Cyclic AMP regulates a vast number of distinct events in all cells. Early studies established that its hydrolysis by cyclic… (More)
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Highly Cited
2007
Highly Cited
2007
Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease.
RATIONALE The oral phosphodiesterase-4 (PDE4) inhibitor, roflumilast, can improve lung function in moderate chronic obstructive… (More)
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Review
2005
Review
2005
Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular concentrations of cyclic AMP, which has a broad… (More)
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Highly Cited
2005
Highly Cited
2005
Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue.
Cyclic nucleotide PDE4 (phosphodiesterase 4) inhibitors are being developed as potent anti-inflammatory drugs for use in chronic… (More)
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Highly Cited
2003
Highly Cited
2003
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant… (More)
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Highly Cited
1999
Highly Cited
1999
Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha.
TNF-alpha mediates both protective and detrimental manifestations of the host immune response. Our previous work has shown… (More)
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