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Cyclic Nucleotide Phosphodiesterases, Type 4

Known as: Type 4 Cyclic Nucleotide Phosphodiesterase, PDE4 Phosphodiesterases, Phosphodiesterase IV 
A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL… 
National Institutes of Health

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Cyclic Nucleotide Phosphodiesterases, Type 4ACyclic Nucleotide Phosphodiesterases, Type 4CCyclic Nucleotide Phosphodiesterases, Type 4DPDE4B protein, human
In BloodProcess of secretionaspects of radiation effectschemical synthesis

Broader (1)

phosphoric diester hydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Natural diarylfluorene derivatives: isolation, total synthesis, and phosphodiesterase-4 inhibition
In our previous study, selaginpulvilins A–D (1–4) featuring an unprecedented 9,9-diphenyl-1-(phenylethynyl)-9H-fluorene skeleton… 
Review
2016
Review
2016
Improvement of Nail and Scalp Psoriasis Using Apremilast in Patients With Chronic Psoriasis: Phase 2b and 3, 52-Week Randomized, Placebo-Controlled Trial Results.
INTRODUCTION A significant portion of patients with psoriasis have scalp and nail involvement. It has been reported that 40% to… 
2015
2015
Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate to severe psoriasis: 52-week results of the ESTEEM 2 Trial
2010
2010
Cross-talk between PI3-kinase and cAMP-Protein Kinase signaling pathways at the level of a Protein Kinase B / -arrestin / cAMP phosphodiesterase-4 complex
2008
2008
Phosphodiesterase 4 inhibitors; current status
2006
2006
Preliminary Study of Herbs on the Influence of Phosphodiesterase 4 Activity
Selective herbal regulators of phosphodiesterase 4(PDE4) were sieved by the influence on PDE4 activity to supply evidence for the… 
2004
2004
Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti‐inflammatory therapeutics
Cyclic nucleotides are powerful signaling molecules and their sole means of removal is through the action of cyclic nucleotide… 
2002
2002
AWD 12-281: Antiasthmatic/antiinflammatory phosphodiesterase 4 inhibitor
Airway diseases such as bronchial asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases whose… 
Review
2000
Review
2000
New phosphodiesterase inhibitors as therapeutics for the treatment of chronic lung disease.
Phosphodiesterase 4 (PDE4) is a member of the growing family cyclic AMP and cyclic GMP. Earliest described inhibitors of PDE4… 
1998
1998
Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains.
Several previous studies have demonstrated that the phosphodiesterase 4 selective inhibitor rolipram affects cellular function at… 
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