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Cyclic Nucleotide Phosphodiesterases, Type 4
Known as:
Type 4 Cyclic Nucleotide Phosphodiesterase
, PDE4 Phosphodiesterases
, Phosphodiesterase IV
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A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL…
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National Institutes of Health
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Related topics
Related topics
13 relations
Narrower (6)
Cyclic Nucleotide Phosphodiesterases, Type 4A
Cyclic Nucleotide Phosphodiesterases, Type 4C
Cyclic Nucleotide Phosphodiesterases, Type 4D
PDE4B protein, human
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In Blood
Process of secretion
aspects of radiation effects
chemical synthesis
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Broader (1)
phosphoric diester hydrolase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Systemic manifestations and comorbidities of COPD
P. Barnes
,
B. Celli
European Respiratory Journal
2009
Corpus ID: 206960000
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow…
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Review
2009
Review
2009
Glucocorticoid resistance in inflammatory diseases
P. Barnes
,
I. Adcock
The Lancet
2009
Corpus ID: 38569193
Highly Cited
2009
Highly Cited
2009
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
L. Fabbri
,
P. Calverley
,
+4 authors
K. Rabe
The Lancet
2009
Corpus ID: 26078824
Highly Cited
2007
Highly Cited
2007
Behavioral Phenotypes of Disc1 Missense Mutations in Mice
S. Clapcote
,
T. Lipina
,
+15 authors
J. Roder
Neuron
2007
Corpus ID: 561290
Review
2005
Review
2005
Keynote review: phosphodiesterase-4 as a therapeutic target.
M. Houslay
,
P. Schafer
,
Kam Y. J. Zhang
Drug discovery today
2005
Corpus ID: 44540151
Highly Cited
2005
Highly Cited
2005
Roflumilast—an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial
K. Rabe
,
E. Bateman
,
D. O’Donnell
,
S. Witte
,
D. Bredenbröker
,
T. Bethke
The Lancet
2005
Corpus ID: 30193324
Review
2005
Review
2005
Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
B. Lipworth
The Lancet
2005
Corpus ID: 23916890
Highly Cited
2004
Highly Cited
2004
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment.
Bing Gong
,
O. Vitolo
,
F. Trinchese
,
Shumin Liu
,
M. Shelanski
,
O. Arancio
The Journal of clinical investigation
2004
Corpus ID: 3662985
Evidence suggests that Alzheimer disease (AD) begins as a disorder of synaptic function, caused in part by increased levels of…
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Review
2003
Review
2003
Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling*
M. Conti
,
W. Richter
,
C. Méhats
,
G. Livera
,
Jy Park
,
C. Jin
The Journal of Biological Chemistry
2003
Corpus ID: 34658491
Highly Cited
1999
Highly Cited
1999
Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha.
L. Corral
,
P. Haslett
,
+6 authors
G. Kaplan
Journal of immunology
1999
Corpus ID: 34824567
TNF-alpha mediates both protective and detrimental manifestations of the host immune response. Our previous work has shown…
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