Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Cyclic Nucleotide Phosphodiesterases, Type 4

Known as: Type 4 Cyclic Nucleotide Phosphodiesterase, PDE4 Phosphodiesterases, Phosphodiesterase IV 
A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL… Expand
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (6)

Cyclic Nucleotide Phosphodiesterases, Type 4ACyclic Nucleotide Phosphodiesterases, Type 4CCyclic Nucleotide Phosphodiesterases, Type 4DPDE4B protein, human
Expand
In BloodProcess of secretionaspects of radiation effectschemical synthesis
Expand

Broader (1)

phosphoric diester hydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases
Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain cells, manifests as an intracellular non… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
Review
2009
Review
2009
Systemic manifestations and comorbidities of COPD
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow… Expand
Review
2009
Review
2009
Glucocorticoid resistance in inflammatory diseases
Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases-including… Expand
Highly Cited
2009
Highly Cited
2009
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The efficacy and safety of… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • table 2
Highly Cited
2007
Highly Cited
2007
Behavioral Phenotypes of Disc1 Missense Mutations in Mice
To support the role of DISC1 in human psychiatric disorders, we identified and analyzed two independently derived ENU-induced… Expand
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • table 1
Highly Cited
2005
Highly Cited
2005
Roflumilast—an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial
BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation associated with… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Review
2005
Review
2005
Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular concentrations of cyclic AMP, which has a broad… Expand
Highly Cited
2004
Highly Cited
2004
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment.
Evidence suggests that Alzheimer disease (AD) begins as a disorder of synaptic function, caused in part by increased levels of… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Review
2003
Review
2003
Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling*
 
Highly Cited
1999
Highly Cited
1999
Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha.
TNF-alpha mediates both protective and detrimental manifestations of the host immune response. Our previous work has shown… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE