Cyclic Nucleotide Phosphodiesterases, Type 4

Known as: Type 4 Cyclic Nucleotide Phosphodiesterase, PDE4 Phosphodiesterases, Phosphodiesterase IV 
A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL… (More)
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow… (More)
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Review
2009
Review
2009
Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases-including… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The efficacy and safety of… (More)
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Highly Cited
2009
Highly Cited
2009
Inhibition of phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP (cAMP), increases phosphorylation… (More)
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Review
2007
Review
2007
Cyclic AMP regulates a vast number of distinct events in all cells. Early studies established that its hydrolysis by cyclic… (More)
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Highly Cited
2007
Highly Cited
2007
RATIONALE The oral phosphodiesterase-4 (PDE4) inhibitor, roflumilast, can improve lung function in moderate chronic obstructive… (More)
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Review
2005
Review
2005
Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular concentrations of cyclic AMP, which has a broad… (More)
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Highly Cited
2005
Highly Cited
2005
Cyclic nucleotide PDE4 (phosphodiesterase 4) inhibitors are being developed as potent anti-inflammatory drugs for use in chronic… (More)
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Highly Cited
2003
Highly Cited
2003
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant… (More)
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Highly Cited
1999
Highly Cited
1999
TNF-alpha mediates both protective and detrimental manifestations of the host immune response. Our previous work has shown… (More)
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