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Cyclic Nucleotide Phosphodiesterases, Type 4

Known as: Type 4 Cyclic Nucleotide Phosphodiesterase, PDE4 Phosphodiesterases, Phosphodiesterase IV 
A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain cells, manifests as an intracellular non… Expand
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Review
2009
Review
2009
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow… Expand
Review
2009
Review
2009
Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases-including… Expand
Highly Cited
2009
Highly Cited
2009
BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The efficacy and safety of… Expand
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Highly Cited
2007
Highly Cited
2007
To support the role of DISC1 in human psychiatric disorders, we identified and analyzed two independently derived ENU-induced… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation associated with… Expand
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Review
2005
Review
2005
Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular concentrations of cyclic AMP, which has a broad… Expand
Highly Cited
2004
Highly Cited
2004
Evidence suggests that Alzheimer disease (AD) begins as a disorder of synaptic function, caused in part by increased levels of… Expand
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Highly Cited
1999
Highly Cited
1999
TNF-alpha mediates both protective and detrimental manifestations of the host immune response. Our previous work has shown… Expand