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Cyclic GMP-Dependent Protein Kinase Type II

Known as: Cyclic GMP Dependent Protein Kinase Type II, cGMP-Dependent Protein Kinase 2, cGMP Dependent Protein Kinase 2 
A cyclic GMP-dependent protein kinase subtype that is expressed predominantly in INTESTINES, BRAIN, and KIDNEY. The protein is myristoylated on its N… Expand
National Institutes of Health

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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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PRKG2 protein, human

Papers overview

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2011
2011
Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Iα.
The cGMP/cGMP-dependent protein kinase (cGK) signaling pathway is implicated in the functional regulation of intracellular… Expand
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2006
2006
Cyclic guanosine 5'-monophosphate-dependent protein kinase II is induced by luteinizing hormone and progesterone receptor-dependent mechanisms in granulosa cells and cumulus oocyte complexes of…
Cyclic GMP (cGMP)-dependent protein kinase II (Prkg2, cGK II) was identified as a potential target of the progesterone receptor… Expand
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Highly Cited
1998
Highly Cited
1998
Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation.
A recently cloned isoform of cGMP-dependent protein kinase (cGK), designated type II, was implicated as the mediator of cGMP… Expand
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1997
1997
cGMP stimulation of cystic fibrosis transmembrane conductance regulator Cl- channels co-expressed with cGMP-dependent protein kinase type II but not type Ibeta.
In order to investigate the involvement of cGMP-dependent protein kinase (cGK) type II in cGMP-provoked intestinal Cl- secretion… Expand
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1997
1997
Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms.
In mammalian tissues two types of cGMP-dependent protein kinase (cGK) have been identified. In contrast to the dimeric cGK I, cGK… Expand
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1996
1996
Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression.
cGMP-based regulatory systems are vital for counteracting the renin-angiotensin system (RAS) which promotes volume expansion and… Expand
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1996
1996
N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II.
The apical membrane of intestinal epithelial cells harbors a unique isozyme of cGMP-dependent protein kinase (cGK type II) which… Expand
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1995
1995
Molecular characterization of a type II cyclic GMP-dependent protein kinase expressed in the rat brain.
We applied reverse transcription-PCR to examine the gene expression of cyclic GMP (cGMP)-dependent protein kinase in the rat… Expand
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1995
1995
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms.
The type I cGMP-dependent protein kinases (cGK I alpha and I beta) form homodimers (subunit M(r) approximately 76,000… Expand
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1994
1994
Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II.
The cDNA for a membrane-associated cGMP-dependent protein kinase (cGK II) was cloned from rat intestine using reverse… Expand
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