FAQ

Cul4A-RING E3 ubiquitin ligase complex

Known as: CDL4 complex, CDL4 complex location, DCX complex location 
A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is… (More)

Topic mentions per year

Topic mentions per year

2004-2015
01220042015

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.
WDTC1/Adp encodes an evolutionarily conserved suppressor of lipid accumulation. While reduced WDTC1 expression is associated with… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2015
2015
CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres.
The mitotic spindle drives chromosome movement during mitosis and attaches to chromosomes at dedicated genomic loci named… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2015
2015
CRL4 is required for efficient CENP-A deposition at centromeres
The mitotic spindle drives chromosome movement during mitosis and attaches to chromosomes at dedicated genomic loci named… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase.
Cdc6 and Cdt1 initiate DNA replication licensing when cells exit mitosis. In cycling cells, Cdc6 is efficiently degraded from… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
Characterization of a Novel DWD Protein that Participates in Heat Stress Response in Arabidopsis
Cullin4-RING ubiquitin ligase (CRL4) is a family of multi-subunit E3 ligases. To investigate the possible involvement of CRL4 in… (More)
Is this relevant?
2013
2013
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
The duration of a woman's reproductive period is determined by the size and persistence of a dormant oocyte pool. Specific oocyte… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2013
2013
HIV relies on neddylation for ubiquitin ligase-mediated functions
HIV and SIV defeat antiviral proteins by usurping Cullin-RING E3 ubiquitin ligases (CRLs) and likely influence other cellular… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2008
2008
Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation.
Many viruses subvert the host ubiquitin-proteasome system to optimize their life cycle. We recently documented such a mechanism… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).
We have recently reported a missense mutation in exon 4 of the tubulin alpha 1A (Tuba1a) gene in a hyperactive N-ethyl-N… (More)
Is this relevant?
2004
2004
Protein degradation: Take a leaf from plants
KAREN VOUSDEN BEATSON INSTITUTE FOR CANCER RESEARCH, GLASGOW, UK The stability of the proto-oncogenic transcription factor c-Jun… (More)
Is this relevant?