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In an attempt to treat cancer patients with ERBB2 overexpressing tumors, we developed a chimeric antigen receptor (CAR) based on… Expand Current neural induction protocols for human embryonic stem (hES) cells rely on embryoid body formation, stromal feeder co… Expand Inflammation is increasingly regarded as a key process underlying metabolic diseases in obese individuals. In particular, obese… Expand Thymectomy in mice on neonatal day 3 leads to the development of multiorgan autoimmune disease due to loss of a CD(+)CD25(+) T… Expand Thymectomy in mice on neonatal day 3 leads to the development of multiorgan autoimmune disease due to loss of a CD+CD25+ T cell… Expand The functional properties of dendritic cells (DCs) are strictly dependent on their maturational state. To analyze the influence… Expand IL-17 is a newly discovered T cell-derived cytokine whose role in osteoclast development has not been fully elucidated. Treatment… Expand The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal… Expand A metabolic pathway of activated macrophages (M phi) involving oxidation of the guanido nitrogens of L-arginine is required for… Expand One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute… Expand