Clonal Deletion

Known as: Clonal Deletions, Deletion, Clonal, Deletions, Clonal 
Removal, via CELL DEATH, of immature lymphocytes that interact with antigens during maturation. For T-lymphocytes this occurs in the thymus and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The thymic medulla is generally held to be a specialized environment for negative selection. However, many self-reactive… (More)
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Highly Cited
2000
Highly Cited
2000
How negative selection shapes a polyclonal population of self-reactive T cells has been difficult to address directly because of… (More)
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Highly Cited
1998
Highly Cited
1998
The folate antagonist methotrexate (MTX) is extensively used in graft-versus-host disease, rheumatoid arthritis, and other… (More)
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Highly Cited
1998
Highly Cited
1998
We recently characterized a CD4+ T cell population expressing the IL-2R alpha chain (CD25), producing IL-10 and resisting clonal… (More)
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Review
1995
Review
1995
Clonal elimination accounts for self-tolerance induction in the thymus and also affects mature T cells responding to exogenous… (More)
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Highly Cited
1991
Highly Cited
1991
CLONAL deletion in the thymus plays a major part in T-cell tolerance to self antigens1–3. But the mechanism of negative selection… (More)
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Highly Cited
1991
Highly Cited
1991
ONE mechanism ensuring self tolerance of T cells is the clonal deletion of thymocytes bearing αβ T-cell receptors1–4. The stage… (More)
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Highly Cited
1990
Highly Cited
1990
The mechanism by which T lymphocytes are tolerized to self or foreign antigens is still controversial. Clonal deletion is the… (More)
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Highly Cited
1989
Highly Cited
1989
To study the fate of developing B cells in the presence and absence of the autoantigens to which they react, chimeric mice were… (More)
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Highly Cited
1989
Highly Cited
1989
Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man. In this paper we show that, for mice… (More)
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