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Clonal Deletion

Known as: Clonal Deletions, Deletion, Clonal, Deletions, Clonal 
Removal, via CELL DEATH, of immature lymphocytes that interact with antigens during maturation. For T-lymphocytes this occurs in the thymus and… 
National Institutes of Health

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Related topics

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AntigensApoptosisClonal AbortionImmunity

Papers overview

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Highly Cited
1998
Highly Cited
1998
Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.
The concept of immunologic tolerance arose from bone marrow transplantation in neonatal or irradiated mice, in which the… 
Review
1997
Review
1997
Immune privilege, T-cell tolerance, and tissue-restricted autoimmunity.
Highly Cited
1994
Highly Cited
1994
Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen.
We have investigated the mechanism of tolerance induced by allogeneic bone marrow transplantation (BMT) in mice conditioned with… 
Highly Cited
1993
Highly Cited
1993
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow
To test whether the product of the bcl-2 proto-oncogene blocks clonal deletion of self-reactive B cells, we have generated… 
Highly Cited
1990
Highly Cited
1990
Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy
Self-tolerance is achieved in part through intrathymic deletion of self- reactive T cells. The necessity of the thymus for this… 
Highly Cited
1990
Highly Cited
1990
Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins.
The exotoxins produced by certain strains of Staphylococcus aureus are able to stimulate powerful polyclonal proliferative… 
Highly Cited
1990
Highly Cited
1990
Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy
T cell tolerance induction was examined in long-term H-2-heterozygous parent----F1 chimeras prepared with supralethal irradiation… 
Highly Cited
1990
Highly Cited
1990
Evidence for involvement of clonal anergy in MHC class I and class II disparate skin allograft tolerance after the termination of intrathymic clonal deletion.
Mechanisms of cyclophosphamide (CP)-induced tolerance to class I (D) and class II (IE) alloantigens were studied. Transplantation… 
Highly Cited
1989
Highly Cited
1989
The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells
We have generated an mAb, RR3-15, that recognizes murine TCRs containing the V beta 11 domain. Using this antibody to stain… 
Highly Cited
1989
Highly Cited
1989
Tolerance-related V beta clonal deletions in normal CD4-8-, TCR- alpha/beta + and abnormal lpr and gld cell populations
We have analyzed tolerance-related clonal deletion of Mls-and I-E- reactive thymocytes at the RNA level using a multi-V beta… 
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