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Clonal Deletion

Known as: Clonal Deletions, Deletion, Clonal, Deletions, Clonal 
Removal, via CELL DEATH, of immature lymphocytes that interact with antigens during maturation. For T-lymphocytes this occurs in the thymus and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2000
Highly Cited
2000
How negative selection shapes a polyclonal population of self-reactive T cells has been difficult to address directly because of… Expand
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Highly Cited
1998
Highly Cited
1998
The folate antagonist methotrexate (MTX) is extensively used in graft-versus-host disease, rheumatoid arthritis, and other… Expand
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Highly Cited
1993
Highly Cited
1993
The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd… Expand
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Highly Cited
1991
Highly Cited
1991
The vast majority of cortical thymocytes die during T cell development while those that survive this selective process accumulate… Expand
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Highly Cited
1991
Highly Cited
1991
To address the mechanisms of tolerance to extrathymic proteins, we have generated transgenic mice expressing the lymphocytic… Expand
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Highly Cited
1990
Highly Cited
1990
In order to examine the mechanisms by which clonal deletion of autoreactive T cells occurs, a peptide antigen was used to induce… Expand
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Highly Cited
1990
Highly Cited
1990
The mechanism by which T lymphocytes are tolerized to self or foreign antigens is still controversial. Clonal deletion is the… Expand
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Highly Cited
1989
Highly Cited
1989
Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man. In this paper we show that, for mice… Expand
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Highly Cited
1989
Highly Cited
1989
The receptors found on most T lymphocytes bind to antigen presented on major histocompatibility complex proteins and consist of… Expand
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Highly Cited
1988
Highly Cited
1988
Immunological tolerance has been demonstrated in double-transgenic mice expressing the genes for a neo-self antigen, hen egg… Expand
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