Clioquinol

Known as: Iodochlorhydroxyquin, Iodochlorhydroxyquinoline, Iodochloroxyquinoline 
An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1945-2018
0102019452017

Papers overview

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2009
2009
The antifungal and amoebicidal drug clioquinol (CQ) was withdrawn from the market when it was linked to an epidemic of subacute… (More)
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2005
2005
Clioquinol, a metal chelator, has been used for many years as an antimicrobial agent and more recently as a potential treatment… (More)
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Highly Cited
2005
Highly Cited
2005
A physiological feature of many tumor tissues and cells is the tendency to accumulate high concentrations of copper. While the… (More)
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Highly Cited
2005
Highly Cited
2005
In investigating the role of metal ions in the pathogenesis of Huntington's disease, we examined the effects of clioquinol, a… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Alzheimer disease (AD) may be caused by the toxic accumulation of beta-amyloid (Abeta). OBJECTIVE To test this… (More)
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Highly Cited
2003
Highly Cited
2003
Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in… (More)
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Highly Cited
2003
Highly Cited
2003
Although the accumulation of the neurotoxic peptide beta amyloid (betaA) in the CNS is a hallmark of Alzheimer's disease, the… (More)
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Highly Cited
2002
Highly Cited
2002
Iron-responsive elements (IREs) are the RNA stem loops that control cellular iron homeostasis by regulating ferritin translation… (More)
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2001
2001
As heavy metal ions may be implicated in the formation of senile plaques in Alzheimer-afflicted brains, treatment with clioquinol… (More)
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Highly Cited
2001
Highly Cited
2001
Inhibition of neocortical beta-amyloid (Abeta) accumulation may be essential in an effective therapeutic intervention for… (More)
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