Cladribine

Known as: CdA, 2-Chlorodeoxyadenosine, 2-CdA 
A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
PURPOSE The goal of this study was to evaluate whether the addition of a purine analog, cladribine or fludarabine, to the… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND On the basis of various clinical and MRI measurements, the phase 3 Cladribine Tablets Treating Multiple Sclerosis… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND An increasing proportion of deaths among human immunodeficiency virus (HIV)-infected persons with access to… (More)
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Highly Cited
2006
Highly Cited
2006
In most patients with systemic mastocytosis (SM), including aggressive SM and mast cell leukemia (MCL), neoplastic cells express… (More)
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Highly Cited
2003
Highly Cited
2003
Patients with systemic mastocytosis (SM) can suffer from disabling symptoms related to mast cell mediator release or mast cell… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE Hairy cell leukemia (HCL) is an uncommon, indolent, chronic B-cell lymphoproliferative disorder involving the marrow and… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To evaluate the safety and efficacy of two doses of cladribine in patients with progressive MS. BACKGROUND Treatment… (More)
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Highly Cited
1998
Highly Cited
1998
Hairy cell leukemia is a chronic B-cell disorder that follows an indolent, but progressive course. Cladribine (2… (More)
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Highly Cited
1996
Highly Cited
1996
A 2-year, placebo-controlled, double-blind, crossover study was started in 1992 to evaluate cladribine, an immunosuppressive drug… (More)
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Highly Cited
1994
Highly Cited
1994
Chronic progressive multiple sclerosis (MS) is a severely disabling demyelinating disease in which autoimmune processes seem to… (More)
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