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Circulating Proteasome

Known as: Circulating Proteasomes, cProteasome 
Cell free proteasome enzyme complexes. Elevated levels of these protein complexes in serum, plasma or blood may be associated with either increased… Expand
National Institutes of Health

Papers overview

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Review
2013
Review
2013
The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes☆
The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the… Expand
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Highly Cited
2011
Highly Cited
2011
Structural Defects in the Regulatory Particle-Core Particle Interface of the Proteasome Induce a Novel Proteasome Stress Response*
Background: Ecm29, a proteasome component, has the unusual property of binding both the regulatory particle (RP) and core… Expand
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2011
2011
The prognostic impact of circulating proteasome concentrations in patients with epithelial ovarian cancer.
BACKGROUND Intracellularly, the ubiquitin-proteasome system participates in crucial functions such as cell cycling… Expand
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Highly Cited
2010
Highly Cited
2010
Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules
Most antigenic peptides presented by MHC class I molecules result from the degradation of intracellular proteins by the… Expand
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Review
2008
Review
2008
Extracellular, circulating proteasomes and ubiquitin - incidence and relevance.
The ubiquitin-proteasome system is the major pathway for intracellular protein degradation and is also deeply involved in the… Expand
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Highly Cited
2006
Highly Cited
2006
Circulating proteasomes are functional and have a subtype pattern distinct from 20S proteasomes in major blood cells.
BACKGROUND 20S proteasomes, the proteolytic core particles of the major intracellular protein degradative pathway, are potential… Expand
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Highly Cited
2003
Highly Cited
2003
Investigations on the maturation and regulation of archaebacterial proteasomes.
The 20S proteasome (core particle, CP) is a multifunctional protease complex and composed of four heptameric subunit rings… Expand
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Highly Cited
2002
Highly Cited
2002
Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases.
OBJECTIVE The 20S proteasome plays a leading immunologic role in the cytosolic generation of MHC class I restricted antigens, and… Expand
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Highly Cited
2000
Highly Cited
2000
The Regulatory Complex of Drosophila melanogaster 26s Proteasomes
Drosophila melanogaster embryos are a source for homogeneous and stable 26S proteasomes suitable for structural studies. For… Expand
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Highly Cited
1993
Highly Cited
1993
MHC-linked LMP gene products specifically alter peptidase activities of the proteasome
PROTEASOMES are highly conserved macromolecular structures which function as endopeptidases1–3. They are found in the cyto-plasm… Expand
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