Cholesterol Monooxygenase (Side-Chain-Cleaving)

Known as: Cytochrome P-450(scc), Steroid 20-22-Lyase, Cytochrome P-450 CYP11A1 
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Mitochondria are essential sites for steroid hormone biosynthesis. Mitochondria in the steroidogenic cells of the adrenal, gonad… (More)
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Review
2005
Review
2005
Circulating aldosterone is principally made in the glomerulosa zone of the adrenal cortex by a series of enzyme steps leading to… (More)
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Highly Cited
2002
Highly Cited
2002
Developmental changes in the expression of 18 Leydig cell-specific mRNA species were measured by real-time polymerase chain… (More)
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Highly Cited
2002
Highly Cited
2002
Recent data implicate locally produced steroids, termed neurosteroids, as regulators of neuronal function. Adrenal and gonadal… (More)
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Highly Cited
2001
Highly Cited
2001
Cytochrome P450scc, the mitochondrial cholesterol side chain cleavage enzyme, is the only enzyme that catalyzes the conversion of… (More)
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2001
2001
The biosynthesis of steroid hormones in endocrine steroid-secreting glands results from a series of successive steps involving… (More)
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Review
2000
Review
2000
The steroidogenic acute regulatory or StAR protein has been shown to be instrumental in the acute regulation of steroid hormone… (More)
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Highly Cited
1998
Highly Cited
1998
Steroidogenic acute regulatory protein (StAR) plays a critical role in steroidogenesis by enhancing the delivery of substrate… (More)
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Highly Cited
1997
Highly Cited
1997
An essential component of regulated steroidogenesis is the translocation of cholesterol from the cytoplasm to the inner… (More)
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Highly Cited
1983
Highly Cited
1983
Rat adrenal mitochondria accumulated cholesterol during ether stress in vivo when side-chain cleavage was inhibited by… (More)
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