Chlorzoxazone

Known as: 5-Chlorobenzoxazolidone, chlorzoxozone, 2-hydroxy-5-chlorobenzoxazole 
A benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Drug-induced liver injury (DILI) is the most common adverse event causing drug nonapprovals and drug withdrawals. Using drugs as… (More)
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2000
2000
We previously demonstrated that 1-ethyl-2-benzimidazolone (1-EBIO) directly activates basolateral membrane calcium-activated K… (More)
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Review
1999
Review
1999
Cigarette smoking remains highly prevalent in most countries. It can affect drug therapy by both pharmacokinetic and… (More)
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Highly Cited
1997
Highly Cited
1997
Benzene is a ubiquitous occupational hematotoxin and leukemogen, but people vary in their response to this toxic agent. To… (More)
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Highly Cited
1997
Highly Cited
1997
AIMS To compare the inhibitory potential of the HIV protease inhibitors saquinavir, ritonavir and indinavir against CYP1A2… (More)
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1997
1997
Chlormethiazole is a sedative and anticonvulsive drug used in the treatment of alcohol withdrawal. Because it had been reported… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND AND OBJECTIVES The hepatic 6-hydroxylation of chlorzoxazone in vitro is mediated primarily by CYP2E1, and measurement… (More)
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1993
1993
Chlorzoxazone, a centrally acting muscle relaxant, was previously shown to be hydroxylated on carbon 6 specifically by cytochrome… (More)
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Highly Cited
1990
Highly Cited
1990
Human cytochrome P-450IIE1 has been implicated in the oxidation of a number of substrates, including protoxins and -carcinogens… (More)
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1983
1983
Twenty-three normal male subjects received 900 mg of acetaminophen and 750 mg of chlorzoxazone as an oral suspension. Analysis of… (More)
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