Chlorzoxazone

Known as: 5-Chlorobenzoxazolidone, chlorzoxozone, 2-hydroxy-5-chlorobenzoxazole 
A benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown… (More)
National Institutes of Health

Related topics

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24 relations

Narrower (3)

6-hydroxychlorzoxazoneParaflexParafon
Chlorzoxazone 500 MG Oral TabletChlorzoxazone 500 MG Oral Tablet [Parafon Forte DSC]Chlorzoxazone:MCnc:Pt:Ser/Plas:QnChlorzoxazone:MCnc:Pt:Urine:Qn
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Broader (2)

Muscle Relaxants, CentralMuscle relaxants

Papers overview

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Highly Cited
2008
Highly Cited
2008
Cellular imaging predictions of clinical drug-induced liver injury.
Drug-induced liver injury (DILI) is the most common adverse event causing drug nonapprovals and drug withdrawals. Using drugs as… (More)
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2000
2000
Stimulation of Cl(-) secretion by chlorzoxazone.
We previously demonstrated that 1-ethyl-2-benzimidazolone (1-EBIO) directly activates basolateral membrane calcium-activated K… (More)
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Review
1999
Review
1999
Drug interactions with tobacco smoking. An update.
Cigarette smoking remains highly prevalent in most countries. It can affect drug therapy by both pharmacokinetic and… (More)
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Highly Cited
1997
Highly Cited
1997
Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone.
Benzene is a ubiquitous occupational hematotoxin and leukemogen, but people vary in their response to this toxic agent. To… (More)
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Highly Cited
1997
Highly Cited
1997
Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir.
AIMS To compare the inhibitory potential of the HIV protease inhibitors saquinavir, ritonavir and indinavir against CYP1A2… (More)
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1997
1997
Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans.
Chlormethiazole is a sedative and anticonvulsive drug used in the treatment of alcohol withdrawal. Because it had been reported… (More)
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Highly Cited
1994
Highly Cited
1994
Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity.
BACKGROUND AND OBJECTIVES The hepatic 6-hydroxylation of chlorzoxazone in vitro is mediated primarily by CYP2E1, and measurement… (More)
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1993
1993
Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone.
Chlorzoxazone, a centrally acting muscle relaxant, was previously shown to be hydroxylated on carbon 6 specifically by cytochrome… (More)
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Highly Cited
1990
Highly Cited
1990
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1.
Human cytochrome P-450IIE1 has been implicated in the oxidation of a number of substrates, including protoxins and -carcinogens… (More)
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1983
1983
Pharmacokinetics of chlorzoxazone in humans.
Twenty-three normal male subjects received 900 mg of acetaminophen and 750 mg of chlorzoxazone as an oral suspension. Analysis of… (More)
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