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Chlorzoxazone

Known as: 5-Chlorobenzoxazolidone, chlorzoxozone, 2-hydroxy-5-chlorobenzoxazole 
A benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown… Expand
National Institutes of Health

Related topics

Related topics

25 relations

Narrower (4)

6-hydroxychlorzoxazoneParaflexParafonParafon Forte DSC
Chlorzoxazone 500 MG Oral TabletChlorzoxazone 500 MG Oral Tablet [Parafon Forte DSC]Chlorzoxazone:MCnc:Pt:Ser/Plas:QnChlorzoxazone:MCnc:Pt:Urine:Qn
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Broader (2)

Muscle Relaxants, CentralMuscle relaxants

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
In Vivo Effects of Goldenseal, Kava Kava, Black Cohosh, and Valerian on Human Cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 Phenotypes
Phytochemical‐mediated modulation of cytochrome P450 (CYP) activity may underlie many herb‐drug interactions. Single‐time point… Expand
Highly Cited
2004
Highly Cited
2004
In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto
Phytochemical‐mediated modulation of cytochrome P450 (CYP) activity may underlie many herb‐drug interactions. Single‐time point… Expand
Highly Cited
2002
Highly Cited
2002
Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
Phytochemical‐mediated modulation of cytochrome P450 (CYP) activity may underlie many herb‐drug interactions. Single‐time point… Expand
Review
1999
Review
1999
Drug Interactions with Tobacco Smoking
Cigarette smoking remains highly prevalent in most countries. It can affect drug therapy by both pharmacokinetic and… Expand
Highly Cited
1998
Highly Cited
1998
Reversed-phase HPLC method for the estimation of acetaminophen, ibuprofen and chlorzoxazone in formulations.
A simple, precise and rapid reversed-phase HPLC method was developed for the simultaneous estimation of acetaminophen, ibuprofen… Expand
Highly Cited
1997
Highly Cited
1997
Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone.
Benzene is a ubiquitous occupational hematotoxin and leukemogen, but people vary in their response to this toxic agent. To… Expand
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Highly Cited
1997
Highly Cited
1997
Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir.
AIMS To compare the inhibitory potential of the HIV protease inhibitors saquinavir, ritonavir and indinavir against CYP1A2… Expand
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Highly Cited
1995
Highly Cited
1995
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s… Expand
Highly Cited
1991
Highly Cited
1991
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.
The role of human cytochrome P-450 IIE1 (P-450 IIE1) in the oxidation of a number of suspect carcinogens was examined by using a… Expand
Highly Cited
1990
Highly Cited
1990
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1.
Human cytochrome P-450IIE1 has been implicated in the oxidation of a number of substrates, including protoxins and -carcinogens… Expand
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