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The oxidative and reductive cytochrome P450 (P450)-mediated chloroform bioactivation has been investigated in human liver… Expand Zileuton, a 5-lipoxygenase inhibitor, was evaluated as an inhibitor of cytochrome P450 activity in human liver microsomes. In the… Expand The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug… Expand Abstract. The subacute toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic… Expand Abstract. To determine whether the CYP2E1 genetic polymorphisms cause alterations in protein expression and enzyme catalytic… Expand Abstract We examined the effect of bisphenol A (BPA) on microsomal cytochrome P450 (P450) enzymes in rats. Rats were treated… Expand Precision-cut human liver slices are an important tool for defining the metabolism and hepatotoxicity of drug candidates early in… Expand As domestic animals such as cat, horse, and dog increasingly become the clinical targets for drug discovery programs, the need to… Expand This study was designed to determine the protective effects of alpha-hederin on chemical-induced liver injury in CF-1 mice and to… Expand Human cytochrome P-450IIE1 has been implicated in the oxidation of a number of substrates, including protoxins and -carcinogens… Expand