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Chlorzoxazone:MCnc:Pt:Urine:Qn
Known as:
????:????:???:??:???
, Chlorzoxazone:Mass Concentration:Point in time:Urine:Quantitative
, Clorzoxazona:MCnc:Pt:Urina:Qn
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3 relations
Chlorzoxazone
Unit of Mass Concentration
Urine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Metabolism of chloroform in the human liver and identification of the competent P450s.
S. Gemma
,
L. Vittozzi
,
E. Testai
Drug Metabolism And Disposition
2003
Corpus ID: 9004094
The oxidative and reductive cytochrome P450 (P450)-mediated chloroform bioactivation has been investigated in human liver…
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Highly Cited
2003
Highly Cited
2003
Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
P. Lu
,
M. Schrag
,
D. Slaughter
,
C. Raab
,
M. Shou
,
A. D. Rodrigues
Drug Metabolism And Disposition
2003
Corpus ID: 22714315
Zileuton, a 5-lipoxygenase inhibitor, was evaluated as an inhibitor of cytochrome P450 activity in human liver microsomes. In the…
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Highly Cited
2002
Highly Cited
2002
Inhibition of cytochromes P450 by antifungal imidazole derivatives.
Wenjian Zhang
,
Yamini Ramamoorthy
,
Tansel Kilicarslan
,
H. Nolte
,
R. Tyndale
,
E. Sellers
Drug Metabolism And Disposition
2002
Corpus ID: 25037349
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug…
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2001
2001
Toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic cytochrome P450 in F344 rats
Toshinari Suzuki
,
Y. Nakagawa
,
K. Tayama
,
K. Yaguchi
,
T. Suga
Archives of Toxicology
2001
Corpus ID: 22330098
Abstract. The subacute toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic…
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2000
2000
Characterization of liver microsomal 7-ethoxycoumarin O-deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene
Kiyoshi Inoue
,
H. Yamazaki
,
T. Shimada
Archives of Toxicology
2000
Corpus ID: 6970008
Abstract. To determine whether the CYP2E1 genetic polymorphisms cause alterations in protein expression and enzyme catalytic…
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Highly Cited
1998
Highly Cited
1998
Suppression of male-specific cytochrome P450 isoforms by bisphenol A in rat liver
N. Hanioka
,
H. Jinno
,
T. Nishimura
,
M. Ando
Archives of Toxicology
1998
Corpus ID: 5676110
Abstract We examined the effect of bisphenol A (BPA) on microsomal cytochrome P450 (P450) enzymes in rats. Rats were treated…
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1998
1998
Alterations of the catalytic activities of drug-metabolizing enzymes in cultures of human liver slices.
M. Vandenbranden
,
S. Wrighton
,
+7 authors
Jensen Cb
Drug Metabolism And Disposition
1998
Corpus ID: 3140622
Precision-cut human liver slices are an important tool for defining the metabolism and hepatotoxicity of drug candidates early in…
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Highly Cited
1997
Highly Cited
1997
In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse.
N. Chauret
,
Annick Gauthier
,
Jean Martin
,
D. Nicoll-Griffith
Drug Metabolism And Disposition
1997
Corpus ID: 8656861
As domestic animals such as cat, horse, and dog increasingly become the clinical targets for drug discovery programs, the need to…
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1995
1995
Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection.
J. Liu
,
Y. Liu
,
P. Bullock
,
C. Klaassen
Toxicology and Applied Pharmacology
1995
Corpus ID: 42613639
This study was designed to determine the protective effects of alpha-hederin on chemical-induced liver injury in CF-1 mice and to…
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Highly Cited
1991
Highly Cited
1991
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1.
R. Peter
,
R. Boecker
,
P. Beaune
,
M. Iwasaki
,
F. Guengerich
,
C. Yang
Chemical Research in Toxicology
1991
Corpus ID: 13050669
Human cytochrome P-450IIE1 has been implicated in the oxidation of a number of substrates, including protoxins and -carcinogens…
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