Chk1 Inhibitor GDC-0575

Known as: Checkpoint Kinase 1 Inhibitor GDC-0575, GDC-0575 
A small molecule inhibitor of cell cycle checkpoint kinase 1 (Chk1), with potential chemosensitization activity. Chk1 inhibitor GDC-0575 specifically… (More)
National Institutes of Health

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Topic mentions per year

2017-2017
0120172017

Papers overview

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2018
2018
Purpose: Checkpoint kinase 1 inhibitors (CHEK1i) have single-agent activity in vitro and in vivo Here, we have investigated the… (More)
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2018
2018
Background Checkpoint kinase 1 (Chk1) inhibition following chemotherapy-elicited DNA damage overrides cell cycle arrest and… (More)
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2018
2018
Background Inhibition of ChK1 appears as a promising strategy for selectively potentiate the efficacy of chemotherapeutic agents… (More)
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2017
2017
Cytarabine (AraC) represents the most effective single agent treatment for AML. Nevertheless, overriding AraC resistance in AML… (More)
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