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Chalones

Known as: Chalones [Chemical/Ingredient], chalone 
Peptides that inhibit mitosis (ANTIMITOTICS). During the 1960's the term referred to crude extracts that inhibited cell proliferation; the activity… 
National Institutes of Health

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G(2) chaloneantichalonehumulusol
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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Review
1979
Review
1979
Control of liver growth by growth inhibitors (chalones).
Chalones are auto-inhibitory factors which control tissue growth by reducing cell multiplication. To belong to this class of… 
1977
1977
The granulocytic chalone-a specific inhibor of granulopoiesis: molecular weight and chemical nature.
Chalones specifically inhibit cell rpoliferation not only in their respective normal cell system, but also in the malignant… 
1974
1974
Inhibition of granulopoiesis in diffusion chambers by a granulocyte chalone.
Abstract : Granulocyte chalone obtained from media conditioned by rat granulocytes was tested on normal and vinblastine treated… 
1974
1974
Lack of an effect of tumor-promoting phorbol esters and of epidermal G1 chalone or DNA synthesis in the epidermis of newborn mice.
Summary An investigation was carried out on the effect of skin and epidermis fractions containing epidermal G 1 chalone and of… 
1973
1973
Epidermal growth inhibitors (Chalones) in dermis and serum
SummaryRecent results have shown that water extracts of mouse skin contains two separate inhibitors of epidermal cell… 
1973
1973
Fibroblast chalone and serum mitogen (anti-chalone).
RECENTLY we reported that extracts of diploid human fibroblasts or of the used medium from the cultivation of these cells in… 
1973
1973
INHIBITION OF GRAFT‐VERSUS‐HOST REACTION BY PREINCUBATION OF THE GRAFT WITH A THYMIC EXTRACT (LYMPHOCYTE CHALONE)
Incubation of parental lymphoid cells with the lymphocyte proliferation inhibitor extracted from the thymus (chalone) prevents… 
Highly Cited
1972
Highly Cited
1972
Diurnal fluctuation and -adrenergic elevation of cyclic AMP in mouse epidermis in vivo.
CATECHOLAMINES exert a remarkable anti-mitotic effect on epidermis in vivo and in vitro and are thought to be essential cofactors… 
Highly Cited
1969
Highly Cited
1969
Delayed inhibition of epidermal DNA synthesis after injection of an aqueous skin extract (Chalone)
ZusammenfassungEinzelne oder wiederholte Injektionen von wäßrigem Extrakt aus Mäusehaut reduzierten die DNA-Synthese in der… 
Highly Cited
1968
Highly Cited
1968
Chalones and Cancer: Melanoma Regression induced by “Chalone”: a New Tumour Inhibiting Principle acting in vivo