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Cell Division Cycle Protein 20 Homolog

Known as: p55CDC 
Cell division cycle protein 20 homolog (499 aa, ~55 kDa) is encoded by the human CDC20 gene. This protein plays a role in metaphase arrest.
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
Taxol is widely used for the treatment of human cancer. Its mechanism ofaction in cells is dependent on drug concentration. At… Expand
Highly Cited
2002
Highly Cited
2002
MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to… Expand
Highly Cited
2001
Highly Cited
2001
Mad1 was first identified in budding yeast as an essential component of the checkpoint system that monitors spindle assembly in… Expand
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Highly Cited
2000
Highly Cited
2000
Using combined immunofluorescence and fluorescence in situ hybridization (FISH) analysis we have extensively characterized the… Expand
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Highly Cited
2000
Highly Cited
2000
Eukaryotic cells have evolved a mechanism that delays the progression of mitosis until condensed chromosomes are properly… Expand
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Highly Cited
1999
Highly Cited
1999
The mitotic checkpoint is thought to be essential for ensuring accurate chromosome segregation by implementing mitotic delay in… Expand
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Highly Cited
1998
Highly Cited
1998
We have investigated the function of p55CDC, a mammalian protein related to Cdc20 and Hct1/Cdh1 in Saccharomyces cerevisiae, and… Expand
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Highly Cited
1998
Highly Cited
1998
Activation of the mitotic checkpoint pathway in response to mitotic spindle damage in eukaryotic cells delays the exit from… Expand
Highly Cited
1997
Highly Cited
1997
  • J. Weinstein
  • The Journal of Biological Chemistry
  • 1997
  • Corpus ID: 36889790
p55Cdc is a mammalian protein that shows high homology to the cell cycle proteins Cdc20p of Saccharomyces cerevisiae and the… Expand
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Highly Cited
1994
Highly Cited
1994
A novel protein, p55CDC, has been identified in cycling mammalian cells. This transcript is readily detectable in all… Expand