FAQ

Cavernous Hemangioma of Brain

Known as: Malformation, Cerebral Cavernous, Malformations, Cerebral Cavernous, Cavernous Malformations, Cerebral 
A disorder characterized by malformations in the structure of the capillaries in the brain. It is caused by mutations in the CCM2, KRIT1 and PDCD10… (More)

Topic mentions per year

Topic mentions per year

1963-2017
05019632017

Related topics

Related topics

7 relations
Autosomal dominant inheritanceCEREBRAL CAVERNOUS MALFORMATIONS 2Cerebral Cavernous Malformations ProteinHeadache
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Cavernous Hemangioma of Brain
Nervous system structure
Seizures
Headache
Autosomal dominant inheritance
Intracranial Hemorrhages

Papers overview

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Highly Cited
2010
Highly Cited
2010
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
Endothelial cell-cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous… (More)
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Highly Cited
2009
Highly Cited
2009
The Cerebral Cavernous Malformation signaling pathway promotes vascular integrity via Rho GTPases
Cerebral cavernous malformation (CCM) is a common vascular dysplasia that affects both systemic and central nervous system blood… (More)
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Highly Cited
2008
Highly Cited
2008
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.
Virtually every mammalian cell, including cardiomyocytes, possesses an intrinsic circadian clock. The role of this… (More)
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Highly Cited
2007
Highly Cited
2007
Surrogate markers of small fiber damage in human diabetic neuropathy.
Surrogate markers of diabetic neuropathy are being actively sought to facilitate the diagnosis, measure the progression, and… (More)
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Highly Cited
2005
Highly Cited
2005
Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations.
Cerebral cavernous malformations (CCMs) are hamartomatous vascular malformations characterized by abnormally enlarged capillary… (More)
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Highly Cited
2001
Highly Cited
2001
Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations.
OBJECTIVES Cerebral cavernous malformations are linked to mutations of the KRIT1 gene at the CCM1 locus and to mutations at two… (More)
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Highly Cited
1999
Highly Cited
1999
Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas
Cavernous angiomas are vascular malformations mostly located in the central nervous system and characterized by enlarged… (More)
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Highly Cited
1999
Highly Cited
1999
Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1).
Cerebral cavernous malformations (CCM) are congenital vascular anomalies of the brain that can cause significant neurological… (More)
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Highly Cited
1998
Highly Cited
1998
Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27.
Cerebral cavernous malformation (CCM) is a Mendelian model of stroke, characterized by focal abnormalities in small intracranial… (More)
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Highly Cited
1991
Highly Cited
1991
Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.
gamma-Aminobutyric acid (GABA)-activated Cl- currents in neonatal rat cortical neurons and in cultured cells engineered for the… (More)
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