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Catechol O-Methyltransferase

Known as: S-Adenosyl-L-methionine:catechol O-methyltransferase, Catechol O-Methyltransferase [Chemical/Ingredient], Catechol O Methyltransferase 
Catechol O-methyltransferase (271 aa, ~30 kDa) is encoded by the human COMT gene. This protein is involved in the metabolism of neurotransmitters.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Opioid analgesics are the standards of care for the treatment of moderate to severe nociceptive pain, particularly in the setting… Expand
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Review
2017
Review
2017
Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with high heritability rates. The contribution… Expand
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Review
2017
Review
2017
BACKGROUND Parkinson's disease (PD) is a neurodegenerative disorder with a prevalence increasing with age. Oxidative stress and… Expand
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Review
2016
Review
2016
For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of… Expand
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Highly Cited
2006
Highly Cited
2006
Catechol-O-methyltransferase (COMT) is a key regulator of pain perception, cognitive function, and affective mood. Three common… Expand
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Highly Cited
2004
Highly Cited
2004
Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the prefrontal cortex of the human brain… Expand
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Highly Cited
2003
Highly Cited
2003
Monamines subserve many critical roles in the brain, and monoaminergic drugs such as amphetamine have a long history in the… Expand
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Review
1999
Review
1999
[Axelrod et al. (1958)][1] first described the enzyme-catalyzed O- methylation of catecholamines and other catechols in the late… Expand
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Highly Cited
1996
Highly Cited
1996
Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism… Expand
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Highly Cited
1995
Highly Cited
1995
Human soluble (S) and membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1.1.6) enzymes have been expressed at… Expand
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