Catechol O-Methyltransferase

Known as: S-Adenosyl-L-methionine:catechol O-methyltransferase, Catechol O-Methyltransferase [Chemical/Ingredient], Catechol O Methyltransferase 
Catechol O-methyltransferase (271 aa, ~30 kDa) is encoded by the human COMT gene. This protein is involved in the metabolism of neurotransmitters.

Topic mentions per year

Topic mentions per year

1961-2017
010020019612017

Papers overview

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Highly Cited
2006
Highly Cited
2006
Catechol-O-methyltransferase (COMT) is a key regulator of pain perception, cognitive function, and affective mood. Three common… (More)
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Highly Cited
2006
Highly Cited
2006
Variations in the gene encoding catechol-O-methyltransferase (COMT) are linked to individual differences in pain sensitivity. A… (More)
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Highly Cited
2005
Highly Cited
2005
The cingulate cortex is richly innervated by dopaminergic projections and plays a critical role in attentional control (AC… (More)
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Highly Cited
2004
Highly Cited
2004
Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the prefrontal cortex of the human brain… (More)
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Highly Cited
2003
Highly Cited
2003
A functional polymorphism in the gene for catechol-O-methyltransferase (COMT) has been shown to affect executive cognition and… (More)
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Highly Cited
1999
Highly Cited
1999
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic… (More)
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Highly Cited
1998
Highly Cited
1998
Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines… (More)
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Highly Cited
1996
Highly Cited
1996
Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism… (More)
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Highly Cited
1995
Highly Cited
1995
Human soluble (S) and membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1.1.6) enzymes have been expressed at… (More)
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Highly Cited
1994
Highly Cited
1994
Human genomic DNA fragments containing catechol O-methyltransferase (COMT) sequences were isolated and the exon-intron structure… (More)
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