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Caspases, Initiator

Known as: Caspases, Initiator [Chemical/Ingredient], Initiator Caspases 
A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein… 
National Institutes of Health

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CASP4 protein, human
In BloodProcess of secretionaspects of radiation effectschemical synthesis

Papers overview

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2017
2017
Novel Anticancer Capacities of Saffron
Thanks to poor diagnosis and very limited treatment options, hepatocellular carcinoma (HCC) continues to lead the list of cancer… 
2012
2012
[The analysis of biochemical markers of MCF-7 cells apoptosis induced by recombinant analog of lactaptin].
Earlier we isolated and characterized human milk pro-apoptotic peptide - lactaptin and generated its engineered analog - RL2. It… 
2011
2011
1 WEE 1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis
2011
2011
The Fas - Fas Ligand apoptotic pathway
Background on apoptosis Cell death can be achieved by two fundamentally different mechanisms, apoptosis and necrosis. Apoptosis… 
2010
2010
Interaction with Sug 1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death
Activation of initiator caspases is dependent on interacting proteins, and Ipaf [ICE (interleukin-1β-converting enzyme)protease… 
2008
2008
Simultaneous imaging of two initiator caspases during cisplatin-induced HeLa apoptosis
Caspase-2 is an initiating caspase required for stress-induced apoptosis in various human cancer cells. Activation of caspase-9… 
2005
2005
Plant Programmed Cell Death, Ethylene and Flower Senescence
Programmed cell death (PCD) applies to cell death that is part of the normal life of multicellular organisms. PCD is found… 
2004
2004
Heat Shock Preconditioning and Eicosanoid Pathways Modulate Caspase 3-Like Activity in Superficially Injured Isolated Guinea Pig Gastric Mucosa
Background: After superficial mucosal injury, the disturbed gastric epithelial continuity is restored by cellular migration… 
2002
2002
Combretastatin-A 4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly ( ADP-ribose ) Polymerase Cleavage 1
We have previously reported that combretastatin-A4 prodrug (CA4P), an antitubulin/antiangiogenic agent isolated from the South… 
2000
2000
Inhibition of IAP's protection by Diablo/Smac: new therapeutic opportunities?
Two papers in the July 7th issue of Cell identify a novel mitochondrial factor with a central role in the modulation of…