Caspases, Initiator

Known as: Caspases, Initiator [Chemical/Ingredient], Initiator Caspases 
A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Apoptosome refers to the adaptor protein complex that mediates the activation of an initiator caspase at the onset of apoptosis… (More)
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Highly Cited
2006
Highly Cited
2006
Activation of 'initiator' (or 'apical') caspases-2, -8 or -9 (refs 1–3) is crucial for induction of apoptosis. These caspases… (More)
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Highly Cited
2004
Highly Cited
2004
Specific adaptors regulate the activation of initiator caspases; for example, FADD and Apaf-1 engage caspases 8 and 9… (More)
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Highly Cited
2004
Highly Cited
2004
Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in… (More)
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Review
2003
Review
2003
The core effectors of apoptosis encompass proteolytic enzymes of the caspase family, which reside as latent precursors in most… (More)
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Review
2002
Review
2002
Death receptor- or mitochondrion-dependent apoptosis is initiated by the recruitment and activation of apical caspases in the… (More)
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Highly Cited
2002
Highly Cited
2002
Regulated cell death and survival play important roles in neural development. Extracellular signals are presumed to regulate… (More)
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Review
2000
Review
2000
Caspases are a large family of evolutionarily conserved proteases found from Caenorhabditis elegans to humans. Although the first… (More)
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Highly Cited
1999
Highly Cited
1999
Autocatalytic activation of initiator caspases is the link between pro-apoptotic signals and the destruction machinery of… (More)
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Review
1998
Review
1998
Apoptosis, a morphologically defined form of physiological cell death, is implemented by a death machinery whose executionary arm… (More)
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