Carboxypeptidase B

Known as: Carboxypeptidase B [Chemical/Ingredient], Protaminase 
A ZINC-dependent carboxypeptidase primary found in the DIGESTIVE SYSTEM. The enzyme catalyzes the preferential cleavage of a C-terminal peptidyl-L… (More)
National Institutes of Health

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CPB1 geneIn BloodProcess of secretionantagonists & inhibitors
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Procarboxypeptidase B

Papers overview

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2011
2011
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.
The immune and coagulation systems are both implicated in the pathogenesis of rheumatoid arthritis (RA). Plasma carboxypeptidase… (More)
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2009
2009
Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets*
Chemerin is a potent chemoattractant for cells expressing the serpentine receptor CMKLR1 (chemokine-like receptor 1), such as… (More)
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2009
2009
Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis.
OBJECTIVE Osteopontin (OPN) is a proinflammatory cytokine that plays an important role in the pathogenesis of rheumatoid… (More)
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Review
2008
Review
2008
Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI).
Thrombin-activatable procarboxypeptidase B (proCPB or thrombin-activatable fibrinolysis inhibitor or TAFI) is a plasma… (More)
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2007
2007
Carboxypeptidases B of Anopheles gambiae as targets for a Plasmodium falciparum transmission-blocking vaccine.
Anopheles gambiae is the major African vector of Plasmodium falciparum, the most deadly species of human malaria parasite and the… (More)
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2004
2004
The intrinsic threshold of the fibrinolytic system is modulated by basic carboxypeptidases, but the magnitude of the antifibrinolytic effect of activated thrombin-activable fibrinolysis inhibitor is…
Activated thrombin-activable fibrinolysis inhibitor (TAFIa) is intrinsically unstable, a property that complicates the study of… (More)
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Highly Cited
1997
Highly Cited
1997
On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase B.
The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhibitor can be converted by… (More)
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Highly Cited
1996
Highly Cited
1996
TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex.
TAFI (thrombin-activatable fibrinolysis inhibitor) is a recently discovered plasma protein that can be activated by thrombin… (More)
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Highly Cited
1995
Highly Cited
1995
Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor.
Previous studies demonstrated that tissue plasminogen activator-induced fibrinolysis in vitro is retarded in the presence of… (More)
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Highly Cited
1991
Highly Cited
1991
Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma.
A novel plasminogen-binding protein has been isolated from human plasma utilizing plasminogen-Sepharose affinity chromatography… (More)
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