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Carboxypeptidase A1

Known as: EC 3.4.17.1, Pancreatic Carboxypeptidase A 
Carboxypeptidase A1 (419 aa, ~47 kDa) is encoded by the human CPA1 gene. This protein plays a role in enzyme metabolism.
National Institutes of Health

Related topics

Related topics

7 relations
CPA1 geneEnzyme GeneHydrolysisPeptidase Gene

Broader (1)

Carboxypeptidase A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Targeted Gene Next‐Generation Sequencing in Chinese Children with Chronic Pancreatitis and Acute Recurrent Pancreatitis
2017
2017
The human digestive tract has proteases capable of gluten hydrolysis
2012
2012
Comparative study on activation mechanism of carboxypeptidase A1, A2 and B: first insights from steered molecular dynamics simulations.
2008
2008
Cloning and secretory expression of human carboxypeptidase A1 and its peptide genes
AIM: To clone human carboxypeptidase A1 and its 4 peptide genes as well as construct recombinant vector for secretory expression… 
2006
2006
Soluble expression of human carboxypeptidase A1 active center in pichia yeast
AIM: To express the human carboxypeptidase A1 (CPA1) active center protein in soluble form in pichia yeast. METHODS: Human CPA1… 
2004
2004
Localization of the rat T-cell receptor β-chain and carboxypeptidase A1 loci to chromosome 4
1999
1999
Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031…
Antibody-directed enzyme prodrug therapy (ADEPT) is a technique to increase antitumor selectivity in cancer chemotherapy. Our… 
Highly Cited
1997
Highly Cited
1997
Toward Antibody-directed Enzyme Prodrug Therapy with the T268G Mutant of Human Carboxypeptidase A1 and Novel in VivoStable Prodrugs of Methotrexate*
Antibody-directed enzyme prodrug therapy (ADEPT) has the potential of greatly enhancing antitumor selectivity of cancer therapy… 
Highly Cited
1996
Highly Cited
1996
Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7.
Despite the evidence that human obesity has strong genetic determinants, efforts at identifying specific genes that influence… 
Highly Cited
1991
Highly Cited
1991
Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin.
The mechanism by which digestive zymogens become activated during acute pancreatitis remains poorly understood. Given the ability… 
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