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Canalicular Multispecific Organic Anion Transporter 1

Known as: ATP-Binding Cassette Sub-Family C Member 2, Multidrug Resistance-Associated Protein 2, Canalicular Multidrug Resistance Protein 
Canalicular multispecific organic anion transporter 1 (1545 aa, ~174 kDa) is encoded by the human ABCC2 gene. This protein is involved in both anion… 
National Institutes of Health

Related topics

Related topics

21 relations
ABCC2 geneAdenosine TriphosphatasesApical Domain of the EpitheliumCellular Membrane

Broader (1)

multidrug resistance-associated protein 2

Papers overview

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Review
2017
Review
2017
Aalborg Universitet Novel understanding of ABC transporters ABCB 1 / MDR / P-glycoprotein , ABCC 2 / MRP 2 , and ABCG 2 / BCRP in colorectal pathophysiology
AIM: To evaluate ATP-binding cassette (ABC) transporters in colonic pathophysiology as they had recently been related to… 
2016
2016
Influence of single nucleotide polymorphisms in ABCB 1 , ABCG 2 and ABCC 2 on clinical outcomes to paclitaxel-platinum chemotherapy in patients with non-small-cell lung cancer
Platinum-based chemotherapy is the most common treatment for non-small cell lung cancer (NSCLC). Expression level of drug… 
2015
2015
Lack of association between ABCC 2 polymorphisms and plasma carbamazepine concentrations or pharmacoresistance in Chinese patients with epilepsy
Multidrug resistance proteins (MRP2, ABCC2) may play a role in drug resistance in epilepsy by limiting gastrointestinal… 
2011
2011
Endotoxin does not alter the pharmacokinetics of micafungin, but it impairs biliary excretion of micafungin via multidrug resistance-associated protein 2 (ABCC2/Mrp2) in rats
Micafungin, a newly developed echinocandin-type antifungal agent, is widely used for the treatment of deep-seated fungal… 
2010
2010
Associations of ABCB1, ABCC2, and ABCG2 Polymorphisms With Irinotecan-Pharmacokinetics and Clinical Outcome in Patients With Advanced Non-Small Cell Lung Cancer. Cancer. 2007;110:138-47
2008
2008
Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy.
The pathogenesis of intrahepatic cholestasis of pregnancy (ICP), a disorder that adversely affects maternal wellbeing and fetal… 
2005
2005
The Xenobiotics Transporters Mrp2 (Abcc2) and Bcrp (Abcg2): Basal Expression, Regulatory Events and their Mechanisms in Obstructive Cholestasis are Gender-specific
2004
2004
Transporter mRNA expression in a conditionally immortalized rat small intestine epithelial cell line (TR-SIE).
Small intestine epithelial cell lines (TR-SIE), which are established from the small intestine of transgenic rats harboring… 
2004
2004
HEPATIC TRANSPORT OF PKI 166 , AN EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR OF THE PYRROLO-PYRIMIDINE CLASS , AND ITS MAIN METABOLITE , ACU 154
PKI166, a specific inhibitor of the tyrosine kinase activity of two epidermal growth factor receptors, was under development for… 
2003
2003
Rolle von nukleären Rezeptoren beim hepatischen und intestinalen Medikamententransport
Die Bioverfugbarkeit von Medikamenten wird wesentlich durch die intestinale Resorption und den hepatischen „first-pass”-Effekt…