Camptothecin Analogue

Known as: Camptothecin Analog 
Any substance based on the structure of camptothecin that stabilizes topoisomerase I-DNA covalent complexes, thereby causing DNA damage and apoptosis… (More)
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Irinotecan is a camptothecin analog used as an anticancer drug. Severe, potentially life-threatening toxicities can occur from… (More)
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2007
2007
We reported previously that NSC606985, a camptothecin analogue, induces apoptosis of acute myeloid leukemia (AML) cells through… (More)
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Highly Cited
2006
Highly Cited
2006
Werner syndrome (WS) is an inherited disorder characterized by premature onset of aging, genomic instability, and increased… (More)
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Highly Cited
2002
Highly Cited
2002
We report the x-ray crystal structure of human topoisomerase I covalently joined to double-stranded DNA and bound to the… (More)
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2000
2000
Homocamptothecin (hCPT), which differs from camptothecin (CPT) by the presence of an additional methylene group in the E-ring… (More)
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Highly Cited
1998
Highly Cited
1998
CPT-11 (irinotecan) is a DNA topoisomerase I inhibitor active against metastatic colorectal carcinoma. We investigated, in a… (More)
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Highly Cited
1995
Highly Cited
1995
PURPOSE A phase I study was undertaken to determine the maximum-tolerated dose (MTD), principal toxicities, and pharmacokinetics… (More)
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1992
1992
We established a cisplatin-resistant human ovarian cancer cell line (HAC2/0.1) from the parent cell line (HAC2/P) by continuous… (More)
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1991
1991
1. To investigate the metabolites and biliary excretion of new camptothecin analogue, irinotecan, the drug was administered i.v… (More)
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Highly Cited
1990
Highly Cited
1990
An early phase II study of a new camptothecin analog and an inhibitor of topoisomerase I, CPT-11, was conducted in 62 patients… (More)
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