Caldesmon, human

Known as: CDM, Caldesmon 
Caldesmon (793 aa, ~93 kDa) is encoded by the human CALD1 gene. This protein is involved in binding to and stabilization of filamentous actin.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1956-2017
020406019562016

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14 relations
Actin-Binding ProteinCALD1 geneCALD1 wt AlleleCell Movement
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Broader (1)

Caldesmon

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Caldesmon, human
Cytoskeleton
Microfilaments
Muscle Contraction
Cytokinesis
Cytoskeletal Modeling

Papers overview

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Highly Cited
2008
Highly Cited
2008
A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks.
It has been shown that stromal-vascular fraction isolated from adipose tissues contains an abundance of CD34+ cells. Histological… (More)
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Highly Cited
2006
Highly Cited
2006
The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells.
Hydrogels based on poly(ethylene glycol) (PEG) are of increasing interest for regenerative medicine applications and are ideal… (More)
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Highly Cited
2006
Highly Cited
2006
Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells.
Smooth muscle is a major component of human tissues and is essential for the normal function of a multitude of organs including… (More)
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Highly Cited
2004
Highly Cited
2004
Characterization of smooth muscle cell and pericyte differentiation in the rat retina in vivo.
PURPOSE To identify and apply a range of suitable mural cell markers and undertake an in vivo characterization of pericyte and… (More)
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Highly Cited
2002
Highly Cited
2002
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins
The Rho family GTPases Rac, Rho and Cdc42 are critical in regulating the actin-based cytoskeleton, cell migration, growth… (More)
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Highly Cited
2001
Highly Cited
2001
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
Cell migration is a fundamental biological process involving membrane polarization and cytoskeletal dynamics, both of which are… (More)
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Highly Cited
1999
Highly Cited
1999
Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions.
Caldesmon is known to inhibit the ATPase activity of actomyosin in a Ca(2+)-calmodulin-regulated manner. Although a nonmuscle… (More)
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Highly Cited
1993
Highly Cited
1993
Calponin and SM 22 as differentiation markers of smooth muscle: spatiotemporal distribution during avian embryonic development.
Calponin and SM 22 are two proteins related in sequence that are particularly abundant in smooth muscle cells. Here, the… (More)
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Highly Cited
1992
Highly Cited
1992
Phenotypic changes of human smooth muscle cells during development: late expression of heavy caldesmon and calponin.
Expression of the regulatory contractile proteins, heavy caldesmon (h-caldesmon) and calponin was studied in human aortic smooth… (More)
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Highly Cited
1981
Highly Cited
1981
Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin.
A calmodulin-binding protein called "caldesmon" was purified from chicken gizzard muscle as the major calmodulin-binding protein… (More)
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