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CYP7A1 gene

Known as: CYP7, cholesterol 7 alpha-monooxygenase, CHOLESTEROL 7-ALPHA-HYDROXYLASE 
This gene is involved in bile acid synthesis and steroid metabolism.
National Institutes of Health

Related topics

Related topics

7 relations
CYP7A1 protein, humanIron ChelationMetabolic Detoxication, DrugMetabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
[CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism].
AIM To investigate the association of the polymorphic variants -204A > C (rs 3808607) in the CYP7A1 gene with the development of… 
2014
2014
Identification and Analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in Cynomolgus Macaques
Cytochromes P450 (P450) are important for not only drug metabolism and toxicity, but also biosynthesis and metabolism of… 
2013
2013
Association of genes involved in bile acid synthesis with the progression of primary biliary cirrhosis in Japanese patients
BackgroundPatients with primary biliary cirrhosis (PBC) exhibit a variety of clinical manifestations and patterns of disease… 
2011
2011
CYP7A1 genotypes and haplotypes associated with hypertension in an obese Han Chinese population
This study investigated the association between single-nucleotide polymorphisms (SNPs; rs3808607 and rs1125226) within the CYP7A1… 
2008
2008
Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Activation of CYP7A1 during Food Restriction and Diabetes Is Still Inhibited by Small Heterodimer Partner*
Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the rate-limiting step in the classic pathway of hepatic bile acid biosynthesis… 
2007
2007
An overlapping binding site in the CYP7A1 promoter allows activation of FXR to override the stimulation by LXRalpha.
The aim of this study was to explore why in rabbits activation of farnesoid X receptor (FXR) is dominant over activated liver X… 
2005
2005
Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.
2004
2004
Molecular mechanism for the potentiation of the transcriptional activity of human liver receptor homolog 1 by steroid receptor coactivator-1.
The liver receptor homolog 1 (LRH-1) belongs to the Fushi tarazu factor 1 nuclear receptor subfamily, and its biological… 
2004
2004
The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated…
In previous work, we showed that the binding of the liver x receptor alpha:peroxisome proliferator-activated receptor alpha… 
2003
2003
ARP-1/COUP-TF II Determines Hepatoma Phenotype by Acting as Both a Transcriptional Repressor of Microsomal Triglyceride Transfer Protein and an Inducer of CYP7A1*
L35 and FAO cells were derived as single cell isolates from H35 cells. Whereas L35 cells do not express microsomal triglyceride… 
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