CYP7A1 gene

Known as: CYP7, cholesterol 7 alpha-monooxygenase, CHOLESTEROL 7-ALPHA-HYDROXYLASE 
This gene is involved in bile acid synthesis and steroid metabolism.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
0204019982018

Papers overview

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Highly Cited
2009
Highly Cited
2009
UNLABELLED Mouse fibroblast growth factor 15 (FGF15) and human ortholog FGF19 have been identified as the bile acid-induced… (More)
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Highly Cited
2005
Highly Cited
2005
The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we demonstrate that fibroblast growth… (More)
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Highly Cited
2005
Highly Cited
2005
Bile acids, steroids, and drugs activate steroid and xenobiotic receptor pregnane X receptor (PXR; NR1I2), which induces human… (More)
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Highly Cited
2002
Highly Cited
2002
Bile acid synthesis plays a critical role in the maintenance of mammalian cholesterol homeostasis. The CYP7A1 gene encodes the… (More)
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Highly Cited
2002
Highly Cited
2002
The in vivo role of the nuclear receptor SHP in feedback regulation of bile acid synthesis was examined. Loss of SHP in mice… (More)
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Highly Cited
2001
Highly Cited
2001
The cholesterol 7alpha-hydroxylase gene (CYP7A1) plays an important role in regulation of bile acid biosynthesis and cholesterol… (More)
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Highly Cited
2001
Highly Cited
2001
Cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the neutral pathway of bile acid biosynthesis, is feedback… (More)
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Highly Cited
2000
Highly Cited
2000
The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of… (More)
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Highly Cited
2000
Highly Cited
2000
Bile acids repress the transcription of cytochrome P450 7A1 (CYP7A1), which catalyzes the rate-limiting step in bile acid… (More)
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Highly Cited
2000
Highly Cited
2000
Cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription is repressed by bile acids. The goal of this study is to elucidate the… (More)
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