CYP3A5 gene

Known as: cytochrome P450 family 3 subfamily A member 5, CP35, PCN3 
This gene is involved in the metabolism of fatty acids, steroids, drugs and xenobiotics. It also plays a role in the metabolism of sex hormones.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
0102019942018

Papers overview

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2011
2011
AIM Recently a SNP of the gene encoding P450 oxidoreductase (POR*28; rs1057868C>T) has been associated with increased in vivo… (More)
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Highly Cited
2006
Highly Cited
2006
Previous investigations of solid organ transplant patients treated with tacrolimus showed that individuals carrying a CYP3A5*1… (More)
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2006
2006
The genetic polymorphism affecting the CYP3A5 enzyme is responsible for interindividual and interethnic variability in the… (More)
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2006
2006
Genetic polymorphisms in biotransformation enzyme CYP3A5 (6986G > A, CYP3A5*3; 14690A > G, CYP3A5*6) and drug transporter ABCB1… (More)
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Highly Cited
2004
Highly Cited
2004
CYP3A4 and CYP3A5 exhibit significant overlap in substrate specificity but can differ in product regioselectivity and formation… (More)
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Highly Cited
2003
Highly Cited
2003
To study mechanisms behind the interindividual variability in CYP3A expression and the relative contribution of the different… (More)
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Highly Cited
2003
Highly Cited
2003
Midazolam, triazolam (TRZ), testosterone, and nifedipine have all been widely used as probes for in vitro metabolism of CYP3A. We… (More)
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Highly Cited
2002
Highly Cited
2002
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The… (More)
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Highly Cited
2002
Highly Cited
2002
We recently demonstrated that a variant allele of CYP3A5 (CYP3A5*3) confers low CYP3A5 expression as a result of improper mRNA… (More)
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Highly Cited
2001
Highly Cited
2001
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid levels and responses to half of all… (More)
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