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CXCR4 Inhibitor POL6326

Known as: POL6326 
An orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. CXCR4… Expand
National Institutes of Health

Papers overview

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2019
2019
Background: Acute myocardial infarction (MI) elicits an inflammatory response that drives tissue repair and adverse cardiac… Expand
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2017
2017
2555Background: Balixafortide (POL6326) is a cyclic peptide and a potent, selective antagonist of the chemokine receptor CXCR4… Expand
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2016
2016
AbstractBackgroundCertain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel… Expand
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2016
2016
2548Background: POL6326 is a cyclic peptide and a potent, selective antagonist of the chemokine receptor CXCR4. Evidence suggests… Expand
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2015
2015
Background: Stem cell mobilization (SCM) with G-CSF is efficient but - although overall safe - inconvenient because of the five… Expand
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2012
2012
Epitopes involved in protein–protein and protein–nucleic acid interactions provide ideal starting points for rational structure… Expand
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Review
2012
Review
2012
CXCL12, also known as SDF-1, is the single natural ligand for chemokine receptors CXCR4 and CXCR7. CXCL12 has angiogenic… Expand
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2010
2010
Abstract 824 In multiple myeloma (MM), the second most common hematological malignancy, high-dose therapy followed by autologous… Expand
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2010
2010
Abstract 2179 The role of SDF-1α /CXCR4 signaling in leukemia cell/bone marrow microenvironment interactions has recently been… Expand
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