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CXCR2-transduced Autologous Tumor Infiltrating Lymphocytes

Known as: CXCR2-transduced Autologous TILs 
A preparation of autologous tumor infiltrating lymphocytes (TILs) that are transduced, ex vivo, with a retroviral vector encoding a gene for CXC… Expand
National Institutes of Health

Related topics

Related topics

4 relations
Antigen SensitizationCytotoxic T-LymphocytesT-Cell Activationimmunopotentiation

Papers overview

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2018
2018
Back from the dead: TIL apoptosis in cancer immune evasion
Tumours from multiple cancer types can be infiltrated by CD8þ T cells (TILs) (Spranger et al, 2016). TILs are thought to be… Expand
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2013
2013
Only a small fraction of tumour-infiltrating immune cells possess special anti-tumour proteins
mune system cells that identify and kill infected and cancerous cells. After recognizing and attaching to a target cell, CL cells… Expand
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Highly Cited
2010
Highly Cited
2010
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
The immune response plays an important role in staving off cancer; however, mechanisms of immunosuppression hinder productive… Expand
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2009
2009
Predicting and controlling the reactivity of immune cell populations against cancer
Heterogeneous cell populations form an interconnected network that determine their collective output. One example of such a… Expand
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Highly Cited
2008
Highly Cited
2008
Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.
Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) after lymphodepletion mediates regression in 50% of patients with… Expand
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Highly Cited
2008
Highly Cited
2008
Impact of tumor-infiltrating T cells on survival in patients with malignant pleural mesothelioma.
OBJECTIVE The aim of the study was to determine the impact of tumor-infiltrating lymphocytes on survival in patients with… Expand
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2006
2006
Targeted in vivo expression of IFN-gamma-inducible protein 10 induces specific antitumor activity.
Although it is known that the chemoattractant effect of IFN-gamma inducible protein 10 (IP-10), a CXC chemokine (CXCL10), plays… Expand
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