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CUBN gene

Known as: INTRINSIC FACTOR-COBALAMIN RECEPTOR, gp280, CUBILIN 
National Institutes of Health

Related topics

Related topics

1 relation
intrinsic factor-cobalamin receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Amelioration of Albuminuria in ROCK1 Knockout Mice with Streptozotocin-Induced Diabetic Kidney Disease
Background: Although blockade of Rho kinase with pharmacologic inhibitors ameliorates renal fibrosis and diabetic kidney disease… 
Review
2010
Review
2010
Molecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs
Importance of the field: Nephrotoxicity limits the clinical use of some antibiotics, cancer chemotherapeutics and diagnostic… 
Highly Cited
2009
Highly Cited
2009
Cubilin and Megalin Co-Localize in the Neonatal Inner Ear
Cubilin and megalin are multifunctional endocytotic receptors expressed in many absorptive epithelia. The receptors have separate… 
Highly Cited
2008
Highly Cited
2008
Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells.
Using target-specific short interfering (si) RNAs, we silenced the tandem endocytic receptors megalin and cubilin genes in… 
Highly Cited
2008
Highly Cited
2008
Urinary protein excretion pattern and renal expression of megalin and cubilin in nephropathic cystinosis.
BACKGROUND Nephropathic cystinosis is the most common cause of inherited renal Fanconi syndrome, caused by mutations in lysosomal… 
Review
2007
Review
2007
Multiligand endocytosis and congenital defects: roles of cubilin, megalin and amnionless.
Cubilin and megalin are multiligand receptors that mediate uptake of extracellular ligands. Their function has extensively been… 
Highly Cited
2006
Highly Cited
2006
Application of a fluorescent cobalamin analogue for analysis of the binding kinetics
Fluorescent probe rhodamine was appended to 5′ OH‐ribose of cobalamin (Cbl). The prepared conjugate, CBC, bound to the… 
Highly Cited
2005
Highly Cited
2005
Light chains are a ligand for megalin.
Cubilin and megalin are giant glycoprotein receptors abundant on the luminal surface of proximal tubular cells of the kidney. We… 
Highly Cited
2003
Highly Cited
2003
Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding.
Surfactant-like particles (SLP) are unilamellar secreted membranes associated with the process of lipid absorption and isolated… 
Highly Cited
2000
Highly Cited
2000
Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor–vitamin B12 by cubilin
Megaloblastic anemia 1 (MGA1) is an autosomal recessive disorder caused by the selective intestinal malabsorption of intrinsic… 
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