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CPSF1 gene

Known as: cleavage and polyadenylation specific factor 1, CLEAVAGE-POLYADENYLATION SPECIFICITY FACTOR, 160-KD SUBUNIT, CPSF160 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection
High myopia is a severe form of nearsightedness, which can result in blindness due to its associated complications. While both… Expand
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2016
2016
The polyadenylation complex of Trypanosoma brucei: Characterization of the functional poly(A) polymerase.
The generation of mature mRNA in the protozoan parasite Trypanosoma brucei requires coupled polyadenylation and trans splicing… Expand
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2016
2016
Genome-wide association for milk production and female fertility traits in Canadian dairy Holstein cattle
BackgroundGenome-wide association studies (GWAS) are a powerful tool for detecting genomic regions explaining variation in… Expand
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2014
2014
MOF-associated complexes ensure stem cell identity and Xist repression
Histone acetyl transferases (HATs) play distinct roles in many cellular processes and are frequently misregulated in cancers… Expand
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2014
2014
TDP-43 regulates β-adducin (Add2) transcript stability.
TDP-43 is an RNA-binding protein involved in several steps of mRNA metabolism including transcription, splicing and stability. It… Expand
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Highly Cited
2014
Highly Cited
2014
CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing.
AAUAAA is the most highly conserved motif in eukaryotic mRNA polyadenylation sites and, in mammals, is specifically recognized by… Expand
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2013
2013
Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.
Interleukin 7 receptor, IL7R, is expressed exclusively on cells of the lymphoid lineage, and its expression is crucial for the… Expand
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2011
2011
cpsf1 is required for definitive HSC survival in zebrafish.
A comprehensive understanding of the genes and pathways regulating hematopoiesis is needed to identify genes causally related to… Expand
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Highly Cited
2009
Highly Cited
2009
A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs.
Metazoan histone mRNAs are unique: their pre-mRNAs contain no introns, and the mRNAs are not polyadenylated, ending instead in a… Expand
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Highly Cited
2004
Highly Cited
2004
Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.
In mammals, polyadenylation of mRNA precursors (pre-mRNAs) by poly(A) polymerase (PAP) depends on cleavage and polyadenylation… Expand
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