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CNTROB gene

Known as: CENTROBIN, PP1221, centrobin, centrosomal BRCA2 interacting protein 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
02420002017

Papers overview

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2014
2014
Centrobin-centrosomal protein 4.1-associated protein (CPAP) interaction promotes CPAP localization to the centrioles during centriole duplication.
Centriole duplication is the process by which two new daughter centrioles are generated from the proximal end of preexisting… (More)
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2013
2013
Centrobin controls mother–daughter centriole asymmetry in Drosophila neuroblasts
During interphase in Drosophila neuroblasts, the Centrobin (CNB)-positive daughter centriole retains pericentriolar material (PCM… (More)
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2013
2013
NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin.
Centrobin was initially identified as a centrosome protein for centriole duplication. Centrobin is also detected outside the… (More)
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2013
2013
Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment.
The amount of pericentriolar matrix at the centrosome is tightly linked to both microtubule nucleation and centriole duplication… (More)
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2012
2012
Genetic polymorphisms in centrobin and Nek2 are associated with breast cancer susceptibility in a Chinese Han population
Centrosome aberrations have been suggested to cause chromosomal instability and aneuploidy, and eventually promote cancer… (More)
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2011
2011
Centrobin–tubulin interaction is required for centriole elongation and stability
Centrobin is a daughter centriole protein that is essential for centrosome duplication. However, the molecular mechanism by which… (More)
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2011
2011
Nek2 and its substrate, centrobin/Nip2, are required for proper meiotic spindle formation of the mouse oocytes.
A typical centrosome consists of a pair of centrioles embedded in a proteinous matrix called pericentriolar material. However… (More)
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2010
2010
Centrobin/NIP2 is a microtubule stabilizer whose activity is enhanced by PLK1 phosphorylation during mitosis.
Centrobin/NIP2 is a centrosomal protein that is required for centrosome duplication. It is also critical for microtubule… (More)
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2007
2007
Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization.
Nek2 is a mitotic kinase whose activity varies during the cell cycle. It is well known that Nek2 is involved in centrosome… (More)
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2005
2005
Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication.
In mammalian cells, the centrosome consists of a pair of centrioles and amorphous pericentriolar material. The pair of centrioles… (More)
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