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CIGB-300

Known as: CK2-targeting Synthetic Peptide CIGB-300 
A synthetic peptide targeting the substrates of casein kinase 2 (CK2), with potential antineoplastic activity. Upon administration and nucleolar… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is considered the most pleiotropic protein… Expand
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Review
2017
Review
2017
CK2 genes are overexpressed in many human cancers, and most often overexpression is associated with worse prognosis. Site… Expand
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2017
2017
OBJECTIVES Casein kinase 2 (CK2) is overexpressed in several types of cancer. It has more than 300 substrates mainly involved in… Expand
2014
2014
CIGB-300 is a novel clinical-stage synthetic peptide that impairs the casein kinase 2 (CK2)-mediated phosphorylation of B23… Expand
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2014
2014
Chronic lymphocytic leukemia (CLL) remains an incurable malignancy, urging for the identifcation of new molecular targets for… Expand
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2011
2011
CK2 represents an oncology target scientifically validated. However, clinical research with inhibitors of the CK2-mediated… Expand
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2010
2010
CIGB-300 is a proapoptotic peptide-based drug that abrogates the CK2-mediated phosphorylation. This peptide has antineoplastic… Expand
Highly Cited
2009
Highly Cited
2009
CIGB-300, formerly known as P15-tat, is a proapoptotic peptide with established antiproliferative activity in vitro and… Expand
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Highly Cited
2008
Highly Cited
2008
Protein Kinase CK2 is a serine-threonine kinase frequently deregulated in many human tumors. Here, we hypothesized that a peptide… Expand
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Highly Cited
2008
Highly Cited
2008
BackgroundCervical cancer is now considered the second leading cause of death among women worldwide, and its incidence has… Expand
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