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CI 980

Known as: CI-980, CI980 
 
National Institutes of Health

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2002
2002
OBJECTIVE The purpose of this phase I/II trial was to determine the maximal tolerated dose of CI-980, and determine efficacy… Expand
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2002
2002
CI-980, (ethyl (S)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b] pyrazine-7-yl) carbamate 2-hydroxyethansulfonate (1:1… Expand
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2000
2000
Introduction: CI-980 is a novel chemotherapeutic agent thatinhibits polymerization of tubulin. Preclinical studies haveindicated… Expand
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1998
1998
CI-980 is a synthetic mitotic inhibitor that binds to tubulin at the colchicine site, inhibiting the polymerization of… Expand
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1998
1998
Doxorubicin and ifosfamide are the two most active agents in the treatment of soft-tissue sarcomas. Patients whose tumors have… Expand
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1997
1997
CI-980 is a chemotherapeutic agent currently in Phase II trials that arrests cellular division by binding to tubulin. It is… Expand
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1997
1997
CI-980 (NSC 613862) is one of a novel class of 1,2-dihydropyrido[3, 4-b]pyrazines that inhibits tubulin polymerization… Expand
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1997
1997
CI-980 is a synthetic mitotic inhibitor that binds to the colchicine binding site of tubulin. It demonstrates broad activity… Expand
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1996
1996
SummaryCI-980, originally synthesized as a potential folate antagonist, is a tubulin-binding mitotic inhibitor currently in… Expand
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1995
1995
CI-980, a 1-deaza-7,8-dihydropteridine, is a novel anticancer agent that is a potent mitotic inhibitor acting as a tubulin binder… Expand
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