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CI 972

Known as: 4H-Pyrrolo(3,2-d)pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-(3-thienylmethyl)-, monohydrochloride, CI-972 
National Institutes of Health

Related topics

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2 relations

Broader (2)

PyrimidinesThiophenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
United States Patent ( 19 ) Secrist , et al . 54 9-SUBSTITUTED-8-UNSUBSTITUTED-9
Comparative in vitro and in vivo activities of two 9-deaza guanine analog inhibitors of purine nucleoside phosphory lase, C-972… 
2005
2005
PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. II. Effects on nucleoside catabolism in human and rat bloodin vitro
Patients with deficiency in purine nucleoside phosphorylase (PNP) have elevated levels of the PNP substrates inosine, guanosine… 
2005
2005
PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR)
Inhibitors of purine nucleoside phosphorylase (PNP) are of interest as potential T-cell-selective immunosuppressive agents and… 
1994
1994
Blockade of nucleoside degradation in monkey whole blood in vitro by CI-1000, a purine nucleoside phosphorylase (PNP) inhibitor.
Purine nucleosides HxR or GdR (2.5 micrograms/mL blood) were added to EDTA-treated cynomolgus monkey whole blood in vitro, alone… 
1994
1994
Evidence for a Pathway Independent from 2′‐Deoxyguanosine and Reversible by IL‐2 by which Purine Nucleoside Phosphorylase Inhibitors Block T‐Cell Proliferation
Patients with homozygous deficiency of purine nucleoside phosphorylase (PNP) present with a T‐cell selective immune deficiency… 
1993
1993
Activities of Two 9‐Deazaguanine Analogue Inhibitors of Purine Nucleoside Phosphorylase, CI‐972 and PD 141955, in Vitro and in Vivo
1992
1992
Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective…
Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme in the purine cascade and has been a target for drug design… 
1992
1992
Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955.
1991
1991
Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972.
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